8-oxo-dGDP phosphatase

8-oxo-dGDP phosphatase
Identifiers
EC number 3.6.1.58
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

8-oxo-dGDP phosphatase (EC 3.6.1.58, NUDT5) is an enzyme with systematic name 8-oxo-dGDP phosphohydrolase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

8-oxo-dGDP + H2O \rightleftharpoons 8-oxo-dGMP + phosphate

The enzyme catalyses the hydrolysis of both 8-oxo-dGDP and 8-oxo-GDP.

References

  1. Ishibashi, T., Hayakawa, H., Ito, R., Miyazawa, M., Yamagata, Y. and Sekiguchi, M. (2005). "Mammalian enzymes for preventing transcriptional errors caused by oxidative damage". Nucleic Acids Res. 33: 3779–3784. doi:10.1093/nar/gki682. PMID 16002790.
  2. Ishibashi, T., Hayakawa, H. and Sekiguchi, M. (2003). "A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides". EMBO Rep. 4 (5): 479–483. doi:10.1038/sj.embor.embor838. PMC 1319193. PMID 12717453.
  3. Kamiya, H., Hori, M., Arimori, T., Sekiguchi, M., Yamagata, Y. and Harashima, H. (2009). "NUDT5 hydrolyzes oxidized deoxyribonucleoside diphosphates with broad substrate specificity". DNA Repair (Amst) 8 (10): 1250–1254. doi:10.1016/j.dnarep.2009.07.011. PMID 19699693.
  4. Ito, R., Sekiguchi, M., Setoyama, D., Nakatsu, Y., Yamagata, Y. and Hayakawa, H. (2011). "Cleavage of oxidized guanine nucleotide and ADP sugar by human NUDT5 protein". J. Biochem. 149 (6): 731–738. doi:10.1093/jb/mvr028. PMID 21389046.
  5. Zha, M., Zhong, C., Peng, Y., Hu, H. and Ding, J. (2006). "Crystal structures of human NUDT5 reveal insights into the structural basis of the substrate specificity". J. Mol. Biol. 364 (5): 1021–1033. doi:10.1016/j.jmb.2006.09.078. PMID 17052728.

External links

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