Small nucleolar RNA SNORA35

Small nucleolar RNA SNORA35
Predicted secondary structure and sequence conservation of SNORA35
Identifiers
Symbol	SNORA35
Alt. Symbols	snoHBI-36
Rfam	RF00566
Other data
RNA type	Gene; snRNA; snoRNA; HACA-box
Domain(s)	Eukaryota
GO	0006396 0005730
SO	0000594

Homo sapiens snoRA35 (also known as HBI-36) is an H/ACA box snoRNA, first cloned from a mouse adult brain cDNA library by Cavaillé et al. (2000),^[1] and found to be specifically expressed in the choroid plexus. Its human orthologue, HBI-36 was discovered by a homology search, and was found to be specifically expressed in the brain. Its gene resides in the second intron of the serotonin receptor 2c (5HT-2c) gene, which is predominantly expressed in choroid plexus epithelial cells. The human 5HT-2c mRNA was predicted to be 2'O-methylated by the C/D box snoRNP HBII-52 at a position also subjected to A:I editing. HBI-36 has no documented RNA target.

References

1. Cavaille, J; Buiting K; Kiefmann M; Lalande M; Brannan CI; Horsthemke B; Bachellerie JP; Brosius J; Huttenhofer A (2000). "Identification of brain-specific and imprinted small nucleolar RNA genes exhibiting an unusual genomic organization". Proc Natl Acad Sci U S A. 97 (26): 14311–14316. doi:10.1073/pnas.250426397. PMC 18915. PMID 11106375.

External links

• Page for Small nucleolar RNA SNORA35 at Rfam
• Entry for HBI-36 at snoRNABase