Small nucleolar RNA SNORA55

Small nucleolar RNA SNORA55
Predicted secondary structure and sequence conservation of SNORA55
Identifiers
Symbol	SNORA55
Alt. Symbols	snoACA55
Rfam	RF00431
Other data
RNA type	Gene; snRNA; snoRNA; HACA-box
Domain(s)	Eukaryota
GO	0006396 0005730
SO	0000594

Small nucleolar RNA SNORA55 (also known as ACA55) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide RNA'. ACA55 was originally cloned from HeLa cells^[1] and belongs to the H/ACA box class of snoRNAs as it has the predicted hairpin-hinge-hairpin-tail structure, has the conserved H/ACA-box motifs and is found associated with GAR1 protein. snoRNA ACA55 is predicted to guide the pseudouridylation of U36 of 18S ribosomal RNA (rRNA). Pseudouridylation is the (isomerisation of the nucleoside uridine) to the different isomeric form pseudouridine.

References

1. Kiss, Arnold M.; Jády, Beáta E.; Bertrand, Edouard; Kiss, Tamás (2004). "Human Box H/ACA Pseudouridylation Guide RNA Machinery". Molecular and Cellular Biology 24 (13): 5797–5807. doi:10.1128/MCB.24.13.5797-5807.2004. PMC 480876. PMID 15199136.

External links

• Page for Small nucleolar RNA SNORA55 at Rfam
• Entry for ACA55 at snoRNABase