Small nucleolar RNA snoR639/H1

Small nucleolar RNA snoR639/H1
Predicted secondary structure and sequence conservation of snoR639
Identifiers
Symbol	snoR639
Rfam	RF00291
Other data
RNA type	Gene; snRNA; snoRNA; HACA-box
Domain(s)	Eukaryota
GO	0006396 0005730
SO	0001263

Small nucleolar RNA snoR639 (also known as snoH1) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide RNA'.

snoR639 was originally identified in a study of Drosophila melanogaster minifly (mfl) gene; snoR639 resides in the intron of this gene.^[1] It was later rediscovered by a large-scale RNomics effort.^[2] snoR639 belongs to the H/ACA box class of snoRNAs as it has the predicted hairpin-hinge-hairpin-tail structure, has the conserved H/ACA-box motifs and is found associated with GAR1 protein.

References

1. Giordano, E; Peluso I; Senger S; Furia M (1999). "minifly, a Drosophila gene required for ribosome biogenesis". J Cell Biol 144 (6): 1123–1133. doi:10.1083/jcb.144.6.1123. PMC 2150573. PMID 10087258.
2. Yuan, G; Klambt C; Bachellerie JP; Brosius J; Huttenhofer A (2003). "RNomics in Drosophila melanogaster: identification of 66 candidates for novel non-messenger RNAs". Nucleic Acids Res 31 (10): 2495–2507. doi:10.1093/nar/gkg361. PMC 156043. PMID 12736298.

External links

• Page for Small nucleolar RNA snoR639/H1 at Rfam