Small nucleolar RNA SNORD110
| Small Nucleolar RNA SNORD110 | |
|---|---|
 | |
| Predicted secondary structure and sequence conservation of SNORD110 | |
| Identifiers | |
| Symbol | SNORD110 |
| Rfam | RF00610 |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; C/D-box |
| Domain(s) | Eukaryota |
| GO | 0006396 0005730 |
| SO | 0000593 |
Small Nucleolar RNA SNORD110 (also known as HBII-55) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.
HBII-55 belongs to the C/D box class of snoRNAs which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1] HBII-55 is predicted to guide the 2'O-ribose methylation of 18S ribosomal RNA (rRNA) at residue U1288.[2]
References
- ↑ Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
- ↑ Lestrade, Laurent; Weber, Michel J. (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research 34 (Supplement 1: Database Issue): D158–D162. doi:10.1093/nar/gkj002. PMC 1347365. PMID 16381836. CiteSeerX: 10
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