Small nucleolar RNA TBR7

Small nucleolar RNA TBR7
Predicted secondary structure and sequence conservation of snoTBR7
Identifiers
Symbol snoTBR7
Rfam RF00295
Other data
RNA type Gene; snRNA; snoRNA; CD-box
Domain(s) Eukaryota
GO 0006396 0005730
SO 0000593

Small nucleolar RNA TBR7 is a non-coding RNA (ncRNA) molecule identified in Trypanosoma brucei which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoRNA TBR7 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1]

TBR7 was one of seventeen snoRNAs identified in Trypanosoma brucei by immunoprecipitation with anti-fibrillarin antibodies.[2] It is predicted to guide the 2'O ribosose methylation of 18s ribosomal RNA (rRNA).

References

  1. Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
  2. Dunbar DA, Wormsley S, Lowe TM, Baserga SJ (2000). "Fibrillarin-associated box C/D small nucleolar RNAs in Trypanosoma brucei. Sequence conservation and implications for 2'-O-ribose methylation of rRNA". J. Biol. Chem. 275 (19): 14767–76. doi:10.1074/jbc.M001180200. PMID 10747997.

External links


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