Small nucleolar RNA SNORD93
Small Nucleolar RNA SNORD93 (also known as HBII-336) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.
SNOR93 belongs to the C/D box class of snoRNAs which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1] This snoRNA is the human orthologue of mouse snoRNA MBII-336.[2]
SNORD93 is predicted to guide the 2'O-ribose methylation of 18S ribosomal RNA (rRNA) residue A576.[3]
References
- ↑ Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
- ↑ Huttenhofer, Alexander; Kiefmann, Martin; Meier-Ewert, Sebastian; O'Brien, John; Lehrach, Hans; Bachellerie, Jean-Pierre; Brosius, Jürgen (1 June 2001). "RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse". The EMBO Journal 20 (11): 2943–2953. doi:10.1093/emboj/20.11.2943. PMC 125495. PMID 11387227.
- ↑ Lestrade, Laurent; Weber, Michel J. (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research 34 (Supplement 1: Database Issue): D158–D162. doi:10.1093/nar/gkj002. PMC 1347365. PMID 16381836. CiteSeerX: 10.1.1.105.7552.
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