Small nucleolar RNA Z196/R39/R59 family

Small nucleolar RNA Z196/R39/R59 family
Predicted secondary structure and sequence conservation of snoZ196
Identifiers
Symbol	snoZ196
Rfam	RF00134
Other data
RNA type	Gene; snRNA; snoRNA; CD-box
Domain(s)	Eukaryota
GO	0006396 0005730
SO	0000593

Small nucleolar RNA Z196/R39/R59 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoRNA Z196/R39/R59 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.^[1]

Plant snoRNA Z196 was identified in a screen of Arabidopsis thaliana.^[2]

References

1. Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
2. Marker, C.; Zemann, A.; Terhörst, T.; Kiefmann, M.; Kastenmayer, J. P.; Green, P.; Bachellerie, J. P.; Brosius, J. R.; Hüttenhofer, A. (10 December 2002). "Experimental RNomics: identification of 140 candidates for small non-messenger RNAs in the plant Arabidopsis thaliana". Current Biology 12 (23): 2002–2013. doi:10.1016/S0960-9822(02)01304-0. PMID 12477388.

External links

• Page for Small nucleolar RNA Z196/R39/R59 family at Rfam