Small nucleolar RNA SNORD17

Small nucleolar RNA SNORD17
Predicted secondary structure and sequence conservation of SNORD17
Identifiers
Symbol SNORD17
Alt. Symbols snoHBI-43
Rfam RF00567
Other data
RNA type Gene; snRNA; snoRNA; C/D-box
Domain(s) Eukaryota
GO 0006396 0005730
SO 0000593

SNORD17 (also known as HBI-43) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

HBI-43 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1]

This snoRNA is the human orthologue of mouse HBI-43.[2] HBII-43 is predicted to guide 2'O-ribose methylation of 28s ribosomal RNA (rRNA) at position U3797.[3] This residue (U3797) is also predicted to be pseudouridylated (the uridine residue is converted to pseudouridine) by the H/ACA box snoRNA ACA48.[3]

References

  1. Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
  2. Huttenhofer, Alexander; Kiefmann, Martin; Meier-Ewert, Sebastian; O'Brien, John; Lehrach, Hans; Bachellerie, Jean-Pierre; Brosius, Jürgen (1 June 2001). "RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse". The EMBO Journal 20 (11): 2943–2953. doi:10.1093/emboj/20.11.2943. PMC 125495. PMID 11387227.
  3. 1 2 Lestrade, Laurent; Weber, Michel J. (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research 34 (Supplement 1: Database Issue): D158–D162. doi:10.1093/nar/gkj002. PMC 1347365. PMID 16381836. CiteSeerX: 10.1.1.105.7552.

External links


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