CCL17

Chemokine (C-C motif) ligand 17
PDB rendering based on 1nr2.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1NR2​, 1NR4​
Identifiers
Symbols	CCL17 ; A-152E5.3; ABCD-2; SCYA17; TARC
External IDs	OMIM: 601520 MGI: 1329039 HomoloGene: 2246 GeneCards: CCL17 Gene
Gene ontology Molecular function • receptor binding • chemokine activity • CCR chemokine receptor binding Cellular component • extracellular region • extracellular space Biological process • monocyte chemotaxis • chemotaxis • inflammatory response • G-protein coupled receptor signaling pathway • cell-cell signaling • multicellular organismal development • neutrophil chemotaxis • positive regulation of GTPase activity • negative regulation of myoblast differentiation • lymphocyte chemotaxis • chemokine-mediated signaling pathway • positive regulation of ERK1 and ERK2 cascade • cellular response to interferon-gamma • cellular response to interleukin-1 • cellular response to tumor necrosis factor Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6361	20295
Ensembl	ENSG00000102970	ENSMUSG00000031780
UniProt	Q92583	Q9R043
RefSeq (mRNA)	NM_002987	NM_011332
RefSeq (protein)	NP_002978	NP_035462
Location (UCSC)	Chr 16: 57.4 – 57.42 Mb	Chr 8: 94.81 – 94.81 Mb
PubMed search

Chemokine (C-C motif) ligand 17 (CCL17) is a small cytokine belonging to the CC chemokine family is also known as thymus and activation regulated chemokine (TARC). CCL17 is expressed constitutively in thymus, but only transiently in phytohemagglutinin-stimulated peripheral blood mononuclear cells.^[1] This chemokine specifically binds and induces chemotaxis in T cells and elicits its effects by interacting with the chemokine receptor CCR4.^[1][2] The gene for CCL17 is located on chromosome 16, in humans, along with other chemokines called CCL22 and CX3CL1.^[3][4]

References

1. Imai T, Yoshida T, Baba M, Nishimura M, Kakizaki M, Yoshie O (1996). "Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus vector". J. Biol. Chem. 271 (35): 21514–21. doi:10.1074/jbc.271.35.21514. PMID 8702936.
2. Imai T, Baba M, Nishimura M, Kakizaki M, Takagi S, Yoshie O (1997). "The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4". J. Biol. Chem. 272 (23): 15036–42. doi:10.1074/jbc.272.23.15036. PMID 9169480.
3. Nomiyama H, Imai T, Kusuda J, Miura R, Callen DF, Yoshie O (1997). "Assignment of the human CC chemokine gene TARC (SCYA17) to chromosome 16q13". Genomics 40 (1): 211–3. doi:10.1006/geno.1996.4552. PMID 9070951.
4. Nomiyama H, Imai T, Kusuda J, Miura R, Callen DF, Yoshie O (1998). "Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13". Cytogenet. Cell Genet. 81 (1): 10–1. doi:10.1159/000015000. PMID 9691168.

Further reading

• Saeki H, Tamaki K (2006). "Thymus and activation regulated chemokine (TARC)/CCL17 and skin diseases.". J. Dermatol. Sci. 43 (2): 75–84. doi:10.1016/j.jdermsci.2006.06.002. PMID 16859899.
• Imai T, Yoshida T, Baba M; et al. (1996). "Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus vector.". J. Biol. Chem. 271 (35): 21514–21. doi:10.1074/jbc.271.35.21514. PMID 8702936.
• Nomiyama H, Imai T, Kusuda J; et al. (1997). "Assignment of the human CC chemokine gene TARC (SCYA17) to chromosome 16q13.". Genomics 40 (1): 211–3. doi:10.1006/geno.1996.4552. PMID 9070951.
• Imai T, Baba M, Nishimura M; et al. (1997). "The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4.". J. Biol. Chem. 272 (23): 15036–42. doi:10.1074/jbc.272.23.15036. PMID 9169480.
• Imai T, Chantry D, Raport CJ; et al. (1998). "Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4.". J. Biol. Chem. 273 (3): 1764–8. doi:10.1074/jbc.273.3.1764. PMID 9430724.
• Bernardini G, Hedrick J, Sozzani S; et al. (1998). "Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor.". Eur. J. Immunol. 28 (2): 582–8. doi:10.1002/(SICI)1521-4141(199802)28:02<582::AID-IMMU582>3.0.CO;2-A. PMID 9521068.
• Nomiyama H, Imai T, Kusuda J; et al. (1998). "Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13.". Cytogenet. Cell Genet. 81 (1): 10–1. doi:10.1159/000015000. PMID 9691168.
• Struyf S, Proost P, Sozzani S; et al. (1998). "Enhanced anti-HIV-1 activity and altered chemotactic potency of NH2-terminally processed macrophage-derived chemokine (MDC) imply an additional MDC receptor.". J. Immunol. 161 (6): 2672–5. PMID 9743322.
• Loftus BJ, Kim UJ, Sneddon VP; et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.". Genomics 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
• Garlisi CG, Xiao H, Tian F; et al. (1999). "The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8.". Eur. J. Immunol. 29 (10): 3210–5. doi:10.1002/(SICI)1521-4141(199910)29:10<3210::AID-IMMU3210>3.0.CO;2-W. PMID 10540332.
• Dias Neto E, Correa RG, Verjovski-Almeida S; et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Ghia P, Transidico P, Veiga JP; et al. (2001). "Chemoattractants MDC and TARC are secreted by malignant B-cell precursors following CD40 ligation and support the migration of leukemia-specific T cells". Blood 98 (3): 533–40. doi:10.1182/blood.V98.3.533. PMID 11468146.
• Morita A, Kikuoka S, Horikawa T; et al. (2002). "Evaluation of human thymus and activation-regulated chemokine concentrations in blood using a new sandwich ELISA based on monoclonal antibodies". Clin. Chim. Acta 322 (1–2): 67–75. doi:10.1016/S0009-8981(02)00131-6. PMID 12104083.
• Basu S, Schaefer TM, Ghosh M; et al. (2003). "Molecular cloning and sequencing of 25 different rhesus macaque chemokine cDNAs reveals evolutionary conservation among C, CC, CXC, AND CX3C families of chemokines". Cytokine 18 (3): 140–8. doi:10.1006/cyto.2002.0875. PMID 12126650.
• D'Ambrosio D, Albanesi C, Lang R; et al. (2002). "Quantitative differences in chemokine receptor engagement generate diversity in integrin-dependent lymphocyte adhesion". J. Immunol. 169 (5): 2303–12. doi:10.4049/jimmunol.169.5.2303. PMID 12193695.
• Matsumoto N, Mukae H, Nakamura-Uchiyama F; et al. (2002). "Elevated levels of thymus and activation-regulated chemokine (TARC) in pleural effusion samples from patients infested with Paragonimus westermani". Clin. Exp. Immunol. 130 (2): 314–8. doi:10.1046/j.1365-2249.2002.01985.x. PMC 1906524. PMID 12390321.
• Zheng X, Nakamura K, Tojo M; et al. (2003). "TGF-beta1-mediated regulation of thymus and activation-regulated chemokine (TARC/CCL17) synthesis and secretion by HaCaT cells co-stimulated with TNF-alpha and IFN-gamma". J. Dermatol. Sci. 30 (2): 154–60. doi:10.1016/S0923-1811(02)00071-3. PMID 12413771.
• Kakinuma T, Nakamura K, Wakugawa M; et al. (2003). "IL-4, but not IL-13, modulates TARC (thymus and activation-regulated chemokine)/CCL17 and IP-10 (interferon-induced protein of 10kDA)/CXCL10 release by TNF-alpha and IFN-gamma in HaCaT cell line". Cytokine 20 (1): 1–6. doi:10.1006/cyto.2002.1965. PMID 12441140.
• Uchida T, Suto H, Ra C; et al. (2003). "Preferential expression of T(h)2-type chemokine and its receptor in atopic dermatitis". Int. Immunol. 14 (12): 1431–8. doi:10.1093/intimm/dxf109. PMID 12456591.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Jones, K (Feb 1, 2013). "Serum CD163 and TARC as disease response biomarkers in classical Hodgkin lymphoma.". Clin Cancer Res 19 (3): 731–42. doi:10.1158/1078-0432.CCR-12-2693. PMID 23224400.