IFNB1

Interferon, beta 1, fibroblast
PDB rendering based on 1au1.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1AU1​
Identifiers
Symbols	IFNB1 ; IFB; IFF; IFNB
External IDs	OMIM: 147640 MGI: 107657 HomoloGene: 1640 GeneCards: IFNB1 Gene
Gene ontology Molecular function • cytokine activity • type I interferon receptor binding Cellular component • extracellular region • extracellular space Biological process • adaptive immune response • T cell activation involved in immune response • B cell activation involved in immune response • natural killer cell activation involved in immune response • humoral immune response • cell surface receptor signaling pathway • blood coagulation • response to virus • cytokine-mediated signaling pathway • natural killer cell activation • B cell differentiation • positive regulation of peptidyl-serine phosphorylation of STAT protein • cellular response to interferon-beta • B cell proliferation • defense response to bacterium • response to exogenous dsRNA • negative regulation of viral genome replication • innate immune response • positive regulation of innate immune response • regulation of MHC class I biosynthetic process • negative regulation of T cell differentiation • positive regulation of transcription from RNA polymerase II promoter • defense response to virus • type I interferon signaling pathway • regulation of type I interferon-mediated signaling pathway • cellular response to exogenous dsRNA • cellular response to dexamethasone stimulus • negative regulation of T-helper 2 cell cytokine production • positive regulation of apoptotic signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3456	15977
Ensembl	ENSG00000171855	ENSMUSG00000048806
UniProt	P01574	P01575
RefSeq (mRNA)	NM_002176	NM_010510
RefSeq (protein)	NP_002167	NP_034640
Location (UCSC)	Chr 9: 21.08 – 21.08 Mb	Chr 4: 88.52 – 88.52 Mb
PubMed search

Interferon beta is a protein that in humans is encoded by the IFNB1 gene.^[1] The natural and recombinant protein forms have antiviral, antibacterial, and anticancer properties.^[2] Interferon beta 1a (tradenames: Avonex and Rebif) and Interferon beta 1b (tradenames: Betaseron/Betaferon) are used as drugs.

References

1. "Entrez Gene: IFNB1 interferon, beta 1, fibroblast".
2. "IFNB1 recombinant protein".

Further reading

• Biron CA, Nguyen KB, Pien GC (2002). "Innate immune responses to LCMV infections: natural killer cells and cytokines.". Curr. Top. Microbiol. Immunol. 263: 7–27. doi:10.1007/978-3-642-56055-2_2. PMID 11987821.
• Conti L, Fantuzzi L, Del Cornò M, et al. (2005). "Immunomodulatory effects of the HIV-1 gp120 protein on antigen presenting cells: implications for AIDS pathogenesis.". Immunobiology 209 (1–2): 99–115. doi:10.1016/j.imbio.2004.02.008. PMID 15481145.
• Bekisz J, Schmeisser H, Hernandez J, et al. (2005). "Human interferons alpha, beta and omega". Growth Factors 22 (4): 243–51. doi:10.1080/08977190400000833. PMID 15621727.
• Copeland KF (2006). "Modulation of HIV-1 transcription by cytokines and chemokines". Mini reviews in medicinal chemistry 5 (12): 1093–101. doi:10.2174/138955705774933383. PMID 16375755.
• Silverman RH, Sengupta DN (1991). "Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes". J. Exp. Pathol. 5 (2): 69–77. PMID 1708818.
• Flores I, Mariano TM, Pestka S (1991). "Human interferon omega (omega) binds to the alpha/beta receptor". J. Biol. Chem. 266 (30): 19875–7. PMID 1834641.
• May LT, Sehgal PB (1985). "On the relationship between human interferon alpha 1 and beta 1 genes". J. Interferon Res. 5 (3): 521–6. PMID 2414376.
• Francois DT, Katona IM, June CH, et al. (1988). "Examination of the inhibitory and stimulatory effects of IFN-alpha, -beta, and -gamma on human B-cell proliferation induced by various B-cell mitogens". Clin. Immunol. Immunopathol. 48 (3): 297–306. doi:10.1016/0090-1229(88)90023-2. PMID 3135963.
• Conradt HS, Egge H, Peter-Katalinic J, et al. (1987). "Structure of the carbohydrate moiety of human interferon-beta secreted by a recombinant Chinese hamster ovary cell line". J. Biol. Chem. 262 (30): 14600–5. PMID 3667593.
• Blank KJ, McKernan LN, Murasko DM (1985). "Poly I:C or IFN-alpha/beta treatment inhibits macrophage induced T cell proliferation". J. Interferon Res. 5 (1): 215–21. doi:10.1089/jir.1985.5.215. PMID 3872918.
• Derynck R, Content J, DeClercq E, et al. (1980). "Isolation and structure of a human fibroblast interferon gene". Nature 285 (5766): 542–7. doi:10.1038/285542a0. PMID 6157094.
• Taniguchi T, Ohno S, Fujii-Kuriyama Y, Muramatsu M (1980). "The nucleotide sequence of human fibroblast interferon cDNA". Gene 10 (1): 11–5. doi:10.1016/0378-1119(80)90138-9. PMID 6157601.
• Houghton M, Easton MA, Stewart AG, et al. (1981). "The complete amino acid sequence of human fibroblast interferon as deduced using synthetic oligodeoxyribonucleotide primers of reverse transcriptase". Nucleic Acids Res. 8 (13): 2885–94. doi:10.1093/nar/8.13.2885. PMC 324132. PMID 6159580.
• Goeddel DV, Shepard HM, Yelverton E, et al. (1981). "Synthesis of human fibroblast interferon by E. coli". Nucleic Acids Res. 8 (18): 4057–74. doi:10.1093/nar/8.18.4057. PMC 324219. PMID 6159584.
• Houghton M, Stewart AG, Doel SM, et al. (1981). "The amino-terminal sequence of human fibroblast interferon as deduced from reverse transcripts obtained using synthetic oligonucleotide primers". Nucleic Acids Res. 8 (9): 1913–31. doi:10.1093/nar/8.9.1913. PMC 324047. PMID 6159597.
• Wetzel R (1981). "Assignment of the disulphide bonds of leukocyte interferon". Nature 289 (5798): 606–7. doi:10.1038/289606a0. PMID 6162107.
• Lawn RM, Adelman J, Franke AE, et al. (1981). "Human fibroblast interferon gene lacks introns". Nucleic Acids Res. 9 (5): 1045–52. doi:10.1093/nar/9.5.1045. PMC 326735. PMID 6164984.
• Shepard HM, Leung D, Stebbing N, Goeddel DV (1982). "A single amino acid change in IFN-beta1 abolishes its antiviral activity". Nature 294 (5841): 563–5. doi:10.1038/294563a0. PMID 6171735.
• Content J, De Wit L, Pierard D, et al. (1982). "Secretory proteins induced in human fibroblasts under conditions used for the production of interferon beta". Proc. Natl. Acad. Sci. U.S.A. 79 (9): 2768–72. doi:10.1073/pnas.79.9.2768. PMC 346287. PMID 6178110.
• Fiers W, Remaut E, Devos R, et al. (1983). "The human fibroblast and human immune interferon genes and their expression in homologous and heterologous cells". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 299 (1094): 29–38. doi:10.1098/rstb.1982.0103. PMID 6183692.