IL17A

Interleukin 17A
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2VXS​, 4HR9​, 4HSA​
Identifiers
Symbols	IL17A ; CTLA8; IL-17; IL-17A; IL17
External IDs	OMIM: 603149 MGI: 107364 HomoloGene: 1651 GeneCards: IL17A Gene
Gene ontology Molecular function • cytokine activity • protein binding Cellular component • extracellular space • cytoplasm • external side of plasma membrane Biological process • protein glycosylation • apoptotic process • inflammatory response • immune response • cell-cell signaling • cell death • positive regulation of necrotic cell death • positive regulation of interleukin-23 production • response to amino acid • positive regulation of osteoclast differentiation • positive regulation of transcription from RNA polymerase II promoter • cellular response to interleukin-1 • cellular response to glucocorticoid stimulus • fibroblast activation • positive regulation of cytokine production involved in inflammatory response Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3605	16171
Ensembl	ENSG00000112115	ENSMUSG00000025929
UniProt	Q16552	Q62386
RefSeq (mRNA)	NM_002190	NM_010552
RefSeq (protein)	NP_002181	NP_034682
Location (UCSC)	Chr 6: 52.19 – 52.19 Mb	Chr 1: 20.73 – 20.73 Mb
PubMed search

Interleukin-17A is a protein that in humans is encoded by the IL17A gene.^[1][2]

The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.^[2]

See also

• Interleukin 17

References

1. Rouvier E, Luciani MF, Mattei MG, Denizot F, Golstein P (Jul 1993). "CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene". J Immunol 150 (12): 5445–56. PMID 8390535.
2. "Entrez Gene: IL17A interleukin 17A".

Further reading

• Gaffen SL (2005). "Biology of recently discovered cytokines: interleukin-17--a unique inflammatory cytokine with roles in bone biology and arthritis.". Arthritis Research & Therapy 6 (6): 240–7. doi:10.1186/ar1444. PMC 1064872. PMID 15535837.
• Lubberts E, Koenders MI, van den Berg WB (2006). "The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models.". Arthritis Research & Therapy 7 (1): 29–37. doi:10.1186/ar1478. PMC 1064899. PMID 15642151.
• Yao Z, Painter SL, Fanslow WC, et al. (1996). "Human IL-17: a novel cytokine derived from T cells.". J. Immunol. 155 (12): 5483–6. PMID 7499828.
• Fossiez F, Djossou O, Chomarat P, et al. (1996). "T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines.". J. Exp. Med. 183 (6): 2593–603. doi:10.1084/jem.183.6.2593. PMC 2192621. PMID 8676080.
• Yao Z, Spriggs MK, Derry JM, et al. (1998). "Molecular characterization of the human interleukin (IL)-17 receptor.". Cytokine 9 (11): 794–800. doi:10.1006/cyto.1997.0240. PMID 9367539.
• Murphy KP, Gagne P, Pazmany C, Moody MD (1998). "Expression of human interleukin-17 in Pichia pastoris: purification and characterization.". Protein Expr. Purif. 12 (2): 208–14. doi:10.1006/prep.1997.0832. PMID 9518462.
• Teunissen MB, Koomen CW, de Waal Malefyt R, et al. (1998). "Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes.". J. Invest. Dermatol. 111 (4): 645–9. doi:10.1046/j.1523-1747.1998.00347.x. PMID 9764847.
• Shalom-Barak T, Quach J, Lotz M (1998). "Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-kappaB.". J. Biol. Chem. 273 (42): 27467–73. doi:10.1074/jbc.273.42.27467. PMID 9765276.
• Shin HC, Benbernou N, Fekkar H, et al. (1999). "Regulation of IL-17, IFN-gamma and IL-10 in human CD8(+) T cells by cyclic AMP-dependent signal transduction pathway.". Cytokine 10 (11): 841–50. doi:10.1006/cyto.1998.0375. PMID 9878122.
• Laan M, Cui ZH, Hoshino H, et al. (1999). "Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways.". J. Immunol. 162 (4): 2347–52. PMID 9973514.
• Kotake S, Udagawa N, Takahashi N, et al. (1999). "IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis.". J. Clin. Invest. 103 (9): 1345–52. doi:10.1172/JCI5703. PMC 408356. PMID 10225978.
• Shin HC, Benbernou N, Esnault S, Guenounou M (1999). "Expression of IL-17 in human memory CD45RO+ T lymphocytes and its regulation by protein kinase A pathway.". Cytokine 11 (4): 257–66. doi:10.1006/cyto.1998.0433. PMID 10328864.
• Andoh A, Takaya H, Makino J, et al. (2001). "Cooperation of interleukin-17 and interferon-gamma on chemokine secretion in human fetal intestinal epithelial cells.". Clin. Exp. Immunol. 125 (1): 56–63. doi:10.1046/j.1365-2249.2001.01588.x. PMC 1906093. PMID 11472426.
• Laan M, Palmberg L, Larsson K, Lindén A (2002). "Free, soluble interleukin-17 protein during severe inflammation in human airways.". Eur. Respir. J. 19 (3): 534–7. doi:10.1183/09031936.02.00280902. PMID 11936535.
• Andoh A, Fujino S, Bamba S, et al. (2002). "IL-17 selectively down-regulates TNF-alpha-induced RANTES gene expression in human colonic subepithelial myofibroblasts.". J. Immunol. 169 (4): 1683–7. doi:10.4049/jimmunol.169.4.1683. PMID 12165487.
• Andoh A, Shimada M, Bamba S, et al. (2002). "Extracellular signal-regulated kinases 1 and 2 participate in interleukin-17 plus tumor necrosis factor-alpha-induced stabilization of interleukin-6 mRNA in human pancreatic myofibroblasts.". Biochim. Biophys. Acta 1591 (1-3): 69–74. doi:10.1016/S0167-4889(02)00250-1. PMID 12183057.
• Hsieh HG, Loong CC, Lin CY (2003). "Interleukin-17 induces src/MAPK cascades activation in human renal epithelial cells.". Cytokine 19 (4): 159–74. doi:10.1006/cyto.2002.1952. PMID 12297109.
• Aggarwal S, Ghilardi N, Xie MH, et al. (2003). "Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17.". J. Biol. Chem. 278 (3): 1910–4. doi:10.1074/jbc.M207577200. PMID 12417590.
• Maertzdorf J, Osterhaus AD, Verjans GM (2003). "IL-17 expression in human herpetic stromal keratitis: modulatory effects on chemokine production by corneal fibroblasts.". J. Immunol. 169 (10): 5897–903. doi:10.4049/jimmunol.169.10.5897. PMID 12421973.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.