CXCL15

Interleukin 8
Identifiers
Symbols	Il8 ; Cxcl15; Scyb15; lungkine; weche
External IDs	MGI: 1339941 GeneCards: Il8 Gene
Gene ontology Molecular function • cytokine activity • interleukin-8 receptor binding • chemokine activity Cellular component • extracellular region • extracellular space Biological process • response to molecule of bacterial origin • chemotaxis • inflammatory response • immune response • cell cycle arrest • hemopoiesis • regulation of cell adhesion • neutrophil chemotaxis • receptor internalization • response to endoplasmic reticulum stress • intracellular signal transduction • regulation of retroviral genome replication • negative regulation of G-protein coupled receptor protein signaling pathway • induction of positive chemotaxis • cellular response to lipopolysaccharide Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	20309	20309
Ensembl	ENSMUSG00000029375	ENSMUSG00000029375
UniProt	Q9WVL7	Q9WVL7
RefSeq (mRNA)	NM_011339	NM_011339
RefSeq (protein)	NP_035469	NP_035469
Location (UCSC)	Chr 5: 90.79 – 90.8 Mb	Chr 5: 91.22 – 91.23 Mb
PubMed search

Chemokine (C-X-C motif) ligand 15 (CXCL15) is a small cytokine belonging to the CXC chemokine family that has been described in the mouse. This chemokine is also known under the name lungkine. CXCL15 is an ELR+ CXC chemokine (it contains the amino acid sequence E-L-R immediately before its CXC motif) that recruits neutrophils during inflammation of the lungs. It is highly abundant in epithelial cells of the lung,^[1] and can also be found in other mucosal organs such as the urogenital and gastrointestinal tracts, and in endocrine organs like the adrenal gland.^[2] The gene for CXCL15 is found on mouse chromosome 5.

References

1. Rossi D, Hurst S, Xu Y, Wang W, Menon S, Coffman R, Zlotnik A (1999). "Lungkine, a novel CXC chemokine, specifically expressed by lung bronchoepithelial cells". J Immunol 162 (9): 5490–7. PMID 10228029.
2. Schmitz J, McCracken V, Dimmitt R, Lorenz R (2007). "Expression of CXCL15 (Lungkine) in Murine Gastrointestinal, Urogenital, and Endocrine Organs". J Histochem Cytochem 55 (5): 515–24. doi:10.1369/jhc.6A7121.2007. PMID 17242461.