IFNA16

Interferon, alpha 16
Identifiers
Symbols	IFNA16 ; IFN-alphaO
External IDs	OMIM: 147580 HomoloGene: 105364 GeneCards: IFNA16 Gene
Gene ontology Molecular function • cytokine activity • type I interferon receptor binding Cellular component • extracellular region • extracellular space Biological process • adaptive immune response • T cell activation involved in immune response • natural killer cell activation involved in immune response • humoral immune response • blood coagulation • cytokine-mediated signaling pathway • B cell differentiation • positive regulation of peptidyl-serine phosphorylation of STAT protein • B cell proliferation • response to exogenous dsRNA • innate immune response • defense response to virus • type I interferon signaling pathway • regulation of type I interferon-mediated signaling pathway Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3449	15967
Ensembl	ENSG00000147885	ENSMUSG00000070904
UniProt	P05015	P07351
RefSeq (mRNA)	NM_002173	NM_010504
RefSeq (protein)	NP_002164	NP_034634
Location (UCSC)	Chr 9: 21.22 – 21.22 Mb	Chr 4: 88.84 – 88.84 Mb
PubMed search

Interferon alpha-16, also known as IFN-alpha-16, is a protein that in humans is encoded by theIFNA16 gene.^[1][2]

References

1. "Entrez Gene: interferon".
2. Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO (October 1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia". Genomics 14 (2): 437–43. doi:10.1016/S0888-7543(05)80238-1. PMID 1385305.

Further reading

• Shirazi Y, Pitha PM (1993). "Interferon alpha-mediated inhibition of human immunodeficiency virus type 1 provirus synthesis in T-cells". Virology 193 (1): 303–12. doi:10.1006/viro.1993.1126. PMID 8438572.
• Chen YH, Böck G, Vornhagen R, et al. (1994). "HIV-1 gp41 enhances major histocompatibility complex class I and ICAM-1 expression on H9 and U937 cells". Int. Arch. Allergy Immunol. 104 (3): 227–31. doi:10.1159/000236670. PMID 7913356.
• Dianzani F, Castilletti C, Gentile M, et al. (1998). "Effects of IFN alpha on late stages of HIV-1 replication cycle". Biochimie 80 (8–9): 745–54. doi:10.1016/S0300-9084(99)80028-5. PMID 9865497.
• Zagury JF, Chams V, Lachgar A, et al. (1995). "Are CD4 and Fas peptide identities of gp120 relevant to the molecular basis of AIDS pathogenesis?". Cell Death Differ. 2 (1): 23–32. PMID 17180012.
• Myers MP, Andersen JN, Cheng A, et al. (2001). "TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B". J. Biol. Chem. 276 (51): 47771–4. doi:10.1074/jbc.C100583200. PMID 11694501.
• Cicala C, Arthos J, Selig SM, et al. (2002). "HIV envelope induces a cascade of cell signals in non-proliferating target cells that favor virus replication". Proc. Natl. Acad. Sci. U.S.A. 99 (14): 9380–5. doi:10.1073/pnas.142287999. PMC 123149. PMID 12089333.
• Schmidt B, Ashlock BM, Foster H, et al. (2005). "HIV-infected cells are major inducers of plasmacytoid dendritic cell interferon production, maturation, and migration". Virology 343 (2): 256–66. doi:10.1016/j.virol.2005.09.059. PMID 16278001.
• Kinzl P, Otani T, Benz R, Minowada J (1997). "Interferon-alpha and -gamma differentially reduce rapid immature T-cell death by contact with HIV-1 carrier cell clones in vitro". Microbiol. Immunol. 41 (9): 709–16. doi:10.1111/j.1348-0421.1997.tb01915.x. PMID 9343822.
• Francis ML, Meltzer MS (1993). "Induction of IFN-alpha by HIV-1 in monocyte-enriched PBMC requires gp120-CD4 interaction but not virus replication". J. Immunol. 151 (4): 2208–16. PMID 8345204.
• Peng G, Lei KJ, Jin W, et al. (2006). "Induction of APOBEC3 family proteins, a defensive maneuver underlying interferon-induced anti-HIV-1 activity". J. Exp. Med. 203 (1): 41–6. doi:10.1084/jem.20051512. PMC 2118075. PMID 16418394.
• Silva LK, Blanton RE, Parrado AR, et al. (2010). "Dengue hemorrhagic fever is associated with polymorphisms in JAK1". Eur. J. Hum. Genet. 18 (11): 1221–7. doi:10.1038/ejhg.2010.98. PMC 2950898. PMID 20588308.
• Yang XR, Liang X, Pfeiffer RM, et al. (2010). "Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations". Fam. Cancer 9 (4): 625–33. doi:10.1007/s10689-010-9356-3. PMC 3233727. PMID 20574843.
• Popik W, Hesselgesser JE, Pitha PM (1998). "Binding of human immunodeficiency virus type 1 to CD4 and CXCR4 receptors differentially regulates expression of inflammatory genes and activates the MEK/ERK signaling pathway". J. Virol. 72 (8): 6406–13. PMC 109793. PMID 9658081.
• Gessani S, Borghi P, Fantuzzi L, et al. (1997). "Induction of cytokines by HIV-1 and its gp120 protein in human peripheral blood monocyte/macrophages and modulation of cytokine response during differentiation". J. Leukoc. Biol. 62 (1): 49–53. PMID 9225992.
• Del Cornò M, Gauzzi MC, Penna G, et al. (2005). "Human immunodeficiency virus type 1 gp120 and other activation stimuli are highly effective in triggering alpha interferon and CC chemokine production in circulating plasmacytoid but not myeloid dendritic cells". J. Virol. 79 (19): 12597–601. doi:10.1128/JVI.79.19.12597-12601.2005. PMC 1211530. PMID 16160188.
• Sen GC, Lengyel P (1992). "The interferon system. A bird's eye view of its biochemistry". J. Biol. Chem. 267 (8): 5017–20. PMID 1371992.
• Taoufik Y, Lantz O, Wallon C, et al. (1997). "Human immunodeficiency virus gp120 inhibits interleukin-12 secretion by human monocytes: an indirect interleukin-10-mediated effect". Blood 89 (8): 2842–8. PMID 9108403.
• Conti L, Fantuzzi L, Del Cornò M, et al. (2004). "Immunomodulatory effects of the HIV-1 gp120 protein on antigen presenting cells: implications for AIDS pathogenesis". Immunobiology 209 (1–2): 99–115. doi:10.1016/j.imbio.2004.02.008. PMID 15481145.
• Schols D, De Clercq E (1996). "Human immunodeficiency virus type 1 gp120 induces anergy in human peripheral blood lymphocytes by inducing interleukin-10 production". J. Virol. 70 (8): 4953–60. PMC 190447. PMID 8764000.
• Ankel H, Capobianchi MR, Frezza F, et al. (1996). "Interferon induction by HIV-1-infected cells: a possible role of sulfatides or related glycolipids". Virology 221 (1): 113–9. doi:10.1006/viro.1996.0357. PMID 8661419.