CCL3

Chemokine (C-C motif) ligand 3
PDB rendering based on 1b50.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1B50​, 1B53​, 2X69​, 2X6G​, 3FPU​, 3H44​, 3KBX​, 4RA8​
Identifiers
Symbols	CCL3 ; G0S19-1; LD78ALPHA; MIP-1-alpha; MIP1A; SCYA3
External IDs	OMIM: 182283 HomoloGene: 88430 GeneCards: CCL3 Gene
Gene ontology Molecular function • protein kinase activity • calcium-dependent protein kinase C activity • protein binding • chemokine activity • phospholipase activator activity • kinase activity • CCR1 chemokine receptor binding • CCR5 chemokine receptor binding • chemoattractant activity • identical protein binding Cellular component • extracellular region • extracellular space • intracellular • cytoplasm • cytosol Biological process • MAPK cascade • osteoblast differentiation • cell activation • monocyte chemotaxis • calcium ion transport • cellular calcium ion homeostasis • exocytosis • chemotaxis • inflammatory response • cytoskeleton organization • G-protein coupled receptor signaling pathway • cell-cell signaling • behavior • regulation of cell shape • response to toxic substance • positive regulation of gene expression • negative regulation of gene expression • T cell chemotaxis • release of sequestered calcium ion into cytosol by sarcoplasmic reticulum • calcium-mediated signaling • signaling • positive regulation of cell migration • negative regulation of bone mineralization • neutrophil chemotaxis • lipopolysaccharide-mediated signaling pathway • positive regulation of tumor necrosis factor production • eosinophil degranulation • protein kinase B signaling • positive regulation of neuron apoptotic process • positive regulation of GTPase activity • astrocyte cell migration • negative regulation by host of viral transcription • negative regulation of osteoclast differentiation • eosinophil chemotaxis • macrophage chemotaxis • lymphocyte chemotaxis • positive regulation of interleukin-1 beta secretion • positive regulation of inflammatory response • positive regulation of calcium-mediated signaling • positive chemotaxis • positive regulation of protein kinase B signaling • positive regulation of calcium ion transport • regulation of sensory perception of pain • chemokine-mediated signaling pathway • positive regulation of ERK1 and ERK2 cascade • response to cholesterol • cellular response to interferon-gamma • cellular response to interleukin-1 • cellular response to tumor necrosis factor • cellular response to organic cyclic compound • granulocyte chemotaxis • positive regulation of calcium ion import • positive regulation of natural killer cell chemotaxis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6348	20302
Ensembl	ENSG00000274221	ENSMUSG00000000982
UniProt	P10147	P10855
RefSeq (mRNA)	NM_002983	NM_011337
RefSeq (protein)	NP_002974	NP_035467
Location (UCSC)	Chr 17: 36.09 – 36.09 Mb	Chr 11: 83.65 – 83.65 Mb
PubMed search

Chemokine (C-C motif) ligand 3 (CCL3) also known as macrophage inflammatory protein 1-alpha (MIP-1-alpha) is a protein that in humans is encoded by the CCL3 gene.^[1]

Function

CCL3 is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes^[2] through binding to the receptors CCR1, CCR4 and CCR5.^[1]

Sherry et al. (1988) demonstrated 2 protein components of MIP1, called by them alpha (CCL3, this protein) and beta (CCL4).^[3][1]

CCL3 produces a monophasic fever of rapid onset whose magnitude is equal to or greater than that of fevers produced with either recombinant human tumor necrosis factor or recombinant human interleukin-1. However, in contrast to these two endogenous pyrogens, the fever induced by MIP-1 is not inhibited by the cyclooxygenase inhibitor ibuprofen and CCL3 may participate in the febrile response that is not mediated through prostaglandin synthesis and clinically cannot be ablated by cyclooxygenase.^[4]

Interactions

CCL3 has been shown to interact with CCL4.^[5] Attracts macrophages, monocytes and neutrophils.

See also

• Macrophage inflammatory proteins

References

1. "Entrez Gene: CCL3 chemokine (C-C motif) ligand 3".
2. Wolpe SD, Davatelis G, Sherry B, Beutler B, Hesse DG, Nguyen HT, Moldawer LL, Nathan CF, Lowry SF, Cerami A (1988). "Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties". The Journal of Experimental Medicine 167 (2): 570–81. doi:10.1084/jem.167.2.570. PMC 2188834. PMID 3279154.
3. Sherry B, Tekamp-Olson P, Gallegos C, Bauer D, Davatelis G, Wolpe SD, Masiarz F, Coit D, Cerami A (1988). "Resolution of the two components of macrophage inflammatory protein 1, and cloning and characterization of one of those components, macrophage inflammatory protein 1 beta". The Journal of Experimental Medicine 168 (6): 2251–9. doi:10.1084/jem.168.6.2251. PMC 2189160. PMID 3058856.
4. Davatelis G, Wolpe SD, Sherry B, Dayer JM, Chicheportiche R, Cerami A (1989). "Macrophage inflammatory protein-1: a prostaglandin-independent endogenous pyrogen". Science (New York, N.Y.) 243 (4894 Pt 1): 1066–8. doi:10.1126/science.2646711. PMID 2646711.
5. Guan E, Wang J, Norcross MA (Apr 2001). "Identification of human macrophage inflammatory proteins 1alpha and 1beta as a native secreted heterodimer". The Journal of Biological Chemistry 276 (15): 12404–9. doi:10.1074/jbc.M006327200. PMID 11278300.

Further reading

• Menten P, Wuyts A, Van Damme J (Dec 2002). "Macrophage inflammatory protein-1". Cytokine & Growth Factor Reviews 13 (6): 455–81. doi:10.1016/S1359-6101(02)00045-X. PMID 12401480.
• Muthumani K, Desai BM, Hwang DS, Choo AY, Laddy DJ, Thieu KP, Rao RG, Weiner DB (Apr 2004). "HIV-1 Vpr and anti-inflammatory activity". DNA and Cell Biology 23 (4): 239–47. doi:10.1089/104454904773819824. PMID 15142381.
• Joseph AM, Kumar M, Mitra D (Jan 2005). "Nef: "necessary and enforcing factor" in HIV infection". Current HIV Research 3 (1): 87–94. doi:10.2174/1570162052773013. PMID 15638726.
• Zhao RY, Elder RT (Mar 2005). "Viral infections and cell cycle G2/M regulation". Cell Research 15 (3): 143–9. doi:10.1038/sj.cr.7290279. PMID 15780175.
• Zhao RY, Bukrinsky M, Elder RT (Apr 2005). "HIV-1 viral protein R (Vpr) & host cellular responses". The Indian Journal of Medical Research 121 (4): 270–86. PMID 15817944.
• Li L, Li HS, Pauza CD, Bukrinsky M, Zhao RY (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions". Cell Research 15 (11-12): 923–34. doi:10.1038/sj.cr.7290370. PMID 16354571.