CCL22

Chemokine (C-C motif) ligand 22
Identifiers
Symbols	CCL22 ; A-152E5.1; ABCD-1; DC/B-CK; MDC; SCYA22; STCP-1
External IDs	OMIM: 602957 MGI: 1306779 HomoloGene: 7529 GeneCards: CCL22 Gene
Gene ontology Molecular function • chemokine activity • CCR chemokine receptor binding Cellular component • extracellular region • extracellular space Biological process • monocyte chemotaxis • chemotaxis • inflammatory response • immune response • signal transduction • G-protein coupled receptor signaling pathway • cell-cell signaling • response to virus • neutrophil chemotaxis • positive regulation of GTPase activity • lymphocyte chemotaxis • chemokine-mediated signaling pathway • positive regulation of ERK1 and ERK2 cascade • cellular response to interferon-gamma • cellular response to interleukin-1 • cellular response to tumor necrosis factor Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6367	20299
Ensembl	ENSG00000102962	ENSMUSG00000031779
UniProt	O00626	O88430
RefSeq (mRNA)	NM_002990	NM_009137
RefSeq (protein)	NP_002981	NP_033163
Location (UCSC)	Chr 16: 57.36 – 57.37 Mb	Chr 8: 94.75 – 94.75 Mb
PubMed search

C-C motif chemokine 22 is a protein that in humans is encoded by the CCL22 gene.^[1][2][3]

The protein encoded by this gene is secreted by dendritic cells and macrophages, and elicits its effects on its target cells by interacting with cell surface chemokine receptors such as CCR4.^[4] The gene for CCL22 is located in human chromosome 16 in a cluster with other chemokines called CX3CL1 and CCL17.^[5][6]

References

1. Godiska R, Chantry D, Raport CJ, Sozzani S, Allavena P, Leviten D, Mantovani A, Gray PW (Jun 1997). "Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells". J Exp Med 185 (9): 1595–604. doi:10.1084/jem.185.9.1595. PMC 2196293. PMID 9151897.
2. Nomiyama H, Imai T, Kusuda J, Miura R, Callen DF, Yoshie O (Oct 1998). "Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13". Cytogenet Cell Genet 81 (1): 10–1. doi:10.1159/000015000. PMID 9691168.
3. "Entrez Gene: CCL22 chemokine (C-C motif) ligand 22".
4. Vulcano M, Albanesi C, Stoppacciaro A, Bagnati R, D'Amico G, Struyf S, Transidico P, Bonecchi R, Del Prete A, Allavena P, Ruco LP, Chiabrando C, Girolomoni G, Mantovani A, Sozzani S (2001). "Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo". Eur. J. Immunol. 31 (3): 812–22. doi:10.1002/1521-4141(200103)31:3<812::AID-IMMU812>3.0.CO;2-L. PMID 11241286.
5. Nomiyama H, Imai T, Kusuda J, Miura R, Callen DF, Yoshie O (1998). "Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13". Cytogenet. Cell Genet. 81 (1): 10–1. doi:10.1159/000015000. PMID 9691168.
6. Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.

Further reading

• Robertson MJ (2002). "Role of chemokines in the biology of natural killer cells.". J. Leukoc. Biol. 71 (2): 173–83. PMID 11818437.
• Gear AR, Camerini D (2003). "Platelet chemokines and chemokine receptors: linking hemostasis, inflammation, and host defense.". Microcirculation (New York, N.Y. : 1994) 10 (3-4): 335–50. doi:10.1038/sj.mn.7800198. PMID 12851650.
• Chang M, McNinch J, Elias C; et al. (1997). "Molecular cloning and functional characterization of a novel CC chemokine, stimulated T cell chemotactic protein (STCP-1) that specifically acts on activated T lymphocytes.". J. Biol. Chem. 272 (40): 25229–37. doi:10.1074/jbc.272.40.25229. PMID 9312138.
• Pal R, Garzino-Demo A, Markham PD; et al. (1997). "Inhibition of HIV-1 infection by the beta-chemokine MDC.". Science 278 (5338): 695–8. doi:10.1126/science.278.5338.695. PMID 9381181.
• Imai T, Chantry D, Raport CJ; et al. (1998). "Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4.". J. Biol. Chem. 273 (3): 1764–8. doi:10.1074/jbc.273.3.1764. PMID 9430724.
• Struyf S, Proost P, Sozzani S; et al. (1998). "Enhanced anti-HIV-1 activity and altered chemotactic potency of NH2-terminally processed macrophage-derived chemokine (MDC) imply an additional MDC receptor.". J. Immunol. 161 (6): 2672–5. PMID 9743322.
• Meucci O, Fatatis A, Simen AA; et al. (1998). "Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity.". Proc. Natl. Acad. Sci. U.S.A. 95 (24): 14500–5. doi:10.1073/pnas.95.24.14500. PMC 24402. PMID 9826729.
• Proost P, Struyf S, Schols D; et al. (1999). "Truncation of macrophage-derived chemokine by CD26/ dipeptidyl-peptidase IV beyond its predicted cleavage site affects chemotactic activity and CC chemokine receptor 4 interaction.". J. Biol. Chem. 274 (7): 3988–93. doi:10.1074/jbc.274.7.3988. PMID 9933589.
• Loftus BJ, Kim UJ, Sneddon VP; et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.". Genomics 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
• Annunziato F, Romagnani P, Cosmi L; et al. (2000). "Macrophage-derived chemokine and EBI1-ligand chemokine attract human thymocytes in different stage of development and are produced by distinct subsets of medullary epithelial cells: possible implications for negative selection.". J. Immunol. 165 (1): 238–46. doi:10.4049/jimmunol.165.1.238. PMID 10861057.
• Vulcano M, Albanesi C, Stoppacciaro A; et al. (2001). "Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo.". Eur. J. Immunol. 31 (3): 812–22. doi:10.1002/1521-4141(200103)31:3<812::AID-IMMU812>3.0.CO;2-L. PMID 11241286.
• Berin MC, Dwinell MB, Eckmann L, Kagnoff MF (2001). "Production of MDC/CCL22 by human intestinal epithelial cells.". Am. J. Physiol. Gastrointest. Liver Physiol. 280 (6): G1217–26. PMID 11352815.
• Lambeir AM, Proost P, Durinx C; et al. (2001). "Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family.". J. Biol. Chem. 276 (32): 29839–45. doi:10.1074/jbc.M103106200. PMID 11390394.
• Wakahara S, Fujii Y, Nakao T; et al. (2002). "Gene expression profiles for Fc epsilon RI, cytokines and chemokines upon Fc epsilon RI activation in human cultured mast cells derived from peripheral blood.". Cytokine 16 (4): 143–52. doi:10.1006/cyto.2001.0958. PMID 11792124.
• Ghia P, Strola G, Granziero L; et al. (2002). "Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22.". Eur. J. Immunol. 32 (5): 1403–13. doi:10.1002/1521-4141(200205)32:5<1403::AID-IMMU1403>3.0.CO;2-Y. PMID 11981828.
• D'Ambrosio D, Albanesi C, Lang R; et al. (2002). "Quantitative differences in chemokine receptor engagement generate diversity in integrin-dependent lymphocyte adhesion.". J. Immunol. 169 (5): 2303–12. doi:10.4049/jimmunol.169.5.2303. PMID 12193695.
• Campbell JD, Stinson MJ, Simons FE, HayGlass KT (2003). "Systemic chemokine and chemokine receptor responses are divergent in allergic versus non-allergic humans.". Int. Immunol. 14 (11): 1255–62. doi:10.1093/intimm/dxf098. PMID 12407016.