JWH-047

JWH-047

Systematic (IUPAC) name
(1-butyl-2-methyl-1H-indol-3-yl)(7-methyl-1-naphthalenyl)methanone
Identifiers
CAS Number	316189-65-8
ChemSpider	35303438
Chemical data
Formula	C25H25NO
Molar mass	355.47 g/mol
SMILES CCCCn1c(c(c2c1cccc2)C(=O)c3cccc4c3cc(cc4)C)C
InChI InChI=1S/C25H25NO/c1-4-5-15-26-18(3)24(21-10-6-7-12-23(21)26)25(27)20-11-8-9-19-14-13-17(2)16-22(19)20/h6-14,16H,4-5,15H2,1-3H3 Key:RQWLYQGWFKBOIY-UHFFFAOYSA-N

JWH-047 is a selective cannabinoid ligand, with a bindining affinity of K_i = 0.9 nM for the CB₂ subtype, and more than 65 times selectivity over the CB₁.^[1]

See also

• JWH-015
• JWH-018
• JWH-019
• JWH-073

References

1. Aung MM, Griffin G, Huffman JW, Wu M-J, Keel C, Yang B, Showalter VM, Abood ME, Martin BR (2000). "Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding". Drug and Alcohol Dependence 60 (2): 133–40. doi:10.1016/S0376-8716(99)00152-0. PMID 10940540.