JWH-120
 | |
| Systematic (IUPAC) name | |
|---|---|
|
(4-methyl-1-naphthalenyl)(1-propyl-1H-indol-3-yl)methanone | |
| Identifiers | |
| CAS Number |
824955-98-8  |
| PubChem | CID 11461586 |
| ChemSpider | 9636426 |
| ChEMBL | CHEMBL497811 |
| Chemical data | |
| Formula | C23H21NO |
| Molar mass | 327.42 g/mol |
| |
| |
JWH-120 is a synthetic cannabimimetic that was discovered by John W. Huffman. It is the N-propyl analog of JWH-122. It is a potent and selective ligand for the CB2 receptor, with a binding affinity of Ki = 6.1 ± 0.7 nM at this subtype, and 173 times selectivity over the CB1 subtype.[1]
See also
References
- ↑ Huffman, J.; et al. (2005). "Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists.". Bioorganic & Medicinal Chemistry 13 (1): 89–112. doi:10.1016/j.bmc.2004.09.050. PMID 15582455.
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