CHRNA9

Cholinergic receptor, nicotinic, alpha 9 (neuronal)
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4D01​, 4UXU​, 4UY2​
Identifiers
Symbols	CHRNA9 ; HSA243342; NACHRA9
External IDs	OMIM: 605116 MGI: 1202403 HomoloGene: 9729 IUPHAR: 469 ChEMBL: 2184 GeneCards: CHRNA9 Gene
Gene ontology Molecular function • acetylcholine-activated cation-selective channel activity • calcium channel activity • acetylcholine receptor activity • acetylcholine-gated cation channel activity • acetylcholine binding Cellular component • cytosol • plasma membrane • integral component of plasma membrane • acetylcholine-gated channel complex • cell junction • neuron projection • synapse • postsynaptic membrane Biological process • signal transduction • positive regulation of cytosolic calcium ion concentration • synaptic transmission • synaptic transmission, cholinergic • neuromuscular synaptic transmission • response to nicotine • regulation of membrane potential • inner ear morphogenesis • neurological system process • detection of mechanical stimulus involved in sensory perception of sound • calcium ion transmembrane transport • cation transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55584	231252
Ensembl	ENSG00000174343	ENSMUSG00000029205
UniProt	Q9UGM1	G3X8Z7
RefSeq (mRNA)	NM_017581	NM_001081104
RefSeq (protein)	NP_060051	NP_001074573
Location (UCSC)	Chr 4: 40.34 – 40.36 Mb	Chr 5: 65.97 – 65.98 Mb
PubMed search

Neuronal acetylcholine receptor subunit alpha-9 is a protein that in humans is encoded by the CHRNA9 gene.^[1]

This gene is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor gene superfamily. It encodes a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. This protein is involved in cochlea hair cell development and is also expressed in the outer hair cells (OHCs) of the adult cochlea. The protein is additionally expressed in keratinocytes, the pituitary gland, B-cells and T-cells.^[1]

Selective block of α9α10 nicotinic acetylcholine receptors by the conotoxin RgIA has been shown to be analgesic in an animal model of nerve injury pain.^[2]

See also

• Nicotinic acetylcholine receptor

References

1. "Entrez Gene: CHRNA9 cholinergic receptor, nicotinic, alpha 9".
2. Vincler M, Wittenauer S, Parker R, Ellison M, Olivera BM, McIntosh JM (November 2006). "Molecular mechanism for analgesia involving specific antagonism of α9α10 nicotinic acetylcholine receptors". Proc. Natl. Acad. Sci. U.S.A. 103 (47): 17880–4. doi:10.1073/pnas.0608715103. PMC 1635975. PMID 17101979.

Further reading

• Nguyen VT, Ndoye A, Grando SA (2000). "Novel Human α9 Acetylcholine Receptor Regulating Keratinocyte Adhesion is Targeted by Pemphigus Vulgaris Autoimmunity". Am. J. Pathol. 157 (4): 1377–91. doi:10.1016/S0002-9440(10)64651-2. PMC 1850172. PMID 11021840.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Sgard F, Charpantier E, Bertrand S; et al. (2002). "A novel human nicotinic receptor subunit, alpha10, that confers functionality to the alpha9-subunit". Mol. Pharmacol. 61 (1): 150–9. doi:10.1124/mol.61.1.150. PMID 11752216.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lustig LR, Peng H (2003). "Chromosome location and characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) gene". Cytogenet. Genome Res. 98 (2–3): 154–9. doi:10.1159/000069804. PMID 12697997.
• Valor LM, Castillo M, Ortiz JA, Criado M (2003). "Transcriptional regulation by activation and repression elements located at the 5'-noncoding region of the human alpha9 nicotinic receptor subunit gene". J. Biol. Chem. 278 (39): 37249–55. doi:10.1074/jbc.M307043200. PMID 12860975.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Peng H, Ferris RL, Matthews T; et al. (2004). "Characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) and alpha (alpha) 10 (CHRNA10) in lymphocytes". Life Sci. 76 (3): 263–80. doi:10.1016/j.lfs.2004.05.031. PMID 15531379.
• Hillier LW, Graves TA, Fulton RS; et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Chernyavsky AI, Arredondo J, Vetter DE, Grando SA (2007). "CENTRAL ROLE OF α9 ACETYLCHOLINE RECEPTOR IN COORDINATING KERATINOCYTE ADHESION AND MOTILITY AT THE INITIATION OF EPITHELIALIZATION". Exp. Cell Res. 313 (16): 3542–55. doi:10.1016/j.yexcr.2007.07.011. PMC 2682983. PMID 17706194.

External links

• CHRNA9 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.