Fyn-related kinase

Fyn-related Src family tyrosine kinase
Identifiers
Symbols	FRK ; GTK; PTK5; RAK
External IDs	OMIM: 606573 MGI: 103265 HomoloGene: 48065 IUPHAR: 2025 ChEMBL: 4223 GeneCards: FRK Gene
EC number	2.7.10.2
Gene ontology Molecular function • non-membrane spanning protein tyrosine kinase activity • receptor binding • protein binding • ATP binding Cellular component • intracellular • nucleus • cytoplasm • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome Biological process • protein phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • negative regulation of cell proliferation • cell migration • actin cytoskeleton organization • cell differentiation • peptidyl-tyrosine autophosphorylation • innate immune response Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2444	14302
Ensembl	ENSG00000111816	ENSMUSG00000019779
UniProt	P42685	Q922K9
RefSeq (mRNA)	NM_002031	NM_001159544
RefSeq (protein)	NP_002022	NP_001153016
Location (UCSC)	Chr 6: 115.93 – 116.06 Mb	Chr 10: 34.48 – 34.61 Mb
PubMed search

Fyn-related kinase (FRK, formerly tyrosine protein kinase 5) is an enzyme that in humans is encoded by the FRK gene.^[1][2]

The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth.^[2]

Interactions

FRK has been shown to interact with retinoblastoma protein.^[3]

References

1. Lee J, Wang Z, Luoh SM, Wood WI, Scadden DT (April 1994). "Cloning of FRK, a novel human intracellular SRC-like tyrosine kinase-encoding gene". Gene 138 (1-2): 247–51. doi:10.1016/0378-1119(94)90817-6. PMID 7510261.
2. "Entrez Gene: FRK fyn-related kinase".
3. Craven, R J; Cance W G; Liu E T (September 1995). "The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb". Cancer Res. (UNITED STATES) 55 (18): 3969–72. ISSN 0008-5472. PMID 7664264.

Further reading

• Serfas MS, Tyner AL (2003). "Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinases.". Oncol. Res. 13 (6-10): 409–19. PMID 12725532.
• Craven RJ, Cance WG, Liu ET (1995). "The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb.". Cancer Res. 55 (18): 3969–72. PMID 7664264.
• Cance WG, Craven RJ, Bergman M; et al. (1995). "Rak, a novel nuclear tyrosine kinase expressed in epithelial cells.". Cell Growth Differ. 5 (12): 1347–55. PMID 7696183.
• Cance WG, Craven RJ, Weiner TM, Liu ET (1993). "Novel protein kinases expressed in human breast cancer.". Int. J. Cancer 54 (4): 571–7. doi:10.1002/ijc.2910540409. PMID 8099900.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Meyer T, Xu L, Chang J; et al. (2003). "Breast cancer cell line proliferation blocked by the Src-related Rak tyrosine kinase.". Int. J. Cancer 104 (2): 139–46. doi:10.1002/ijc.10925. PMID 12569567.
• Watanabe T, Ohnuma T, Shibata N; et al. (2004). "No genetic association between Fyn kinase gene polymorphisms (-93A/G, IVS10+37T/C and Ex12+894T/G) and Japanese sporadic Alzheimer's disease.". Neurosci. Lett. 360 (1-2): 109–11. doi:10.1016/j.neulet.2004.02.046. PMID 15082191.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Zhang Y, Wolf-Yadlin A, Ross PL; et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.". Mol. Cell Proteomics 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.