FLT1

Fms-related tyrosine kinase 1
PDB rendering based on 1flt.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1FLT​, 1QSV​, 1QSZ​, 1QTY​, 1RV6​, 2XAC​, 3HNG​, 4CKV​, 4CL7​
Identifiers
Symbols	FLT1 ; FLT; FLT-1; VEGFR-1; VEGFR1
External IDs	OMIM: 165070 MGI: 95558 HomoloGene: 134179 ChEMBL: 1868 GeneCards: FLT1 Gene
EC number	2.7.10.1
Gene ontology Molecular function • transmembrane receptor protein tyrosine kinase activity • vascular endothelial growth factor-activated receptor activity • protein binding • ATP binding • growth factor binding • VEGF-A-activated receptor activity • VEGF-B-activated receptor activity • placental growth factor-activated receptor activity Cellular component • extracellular space • endosome • plasma membrane • integral component of plasma membrane • focal adhesion • receptor complex Biological process • angiogenesis • monocyte chemotaxis • transmembrane receptor protein tyrosine kinase signaling pathway • positive regulation of cell proliferation • positive regulation of phospholipase C activity • positive regulation of phosphatidylinositol 3-kinase signaling • cell migration • peptidyl-tyrosine phosphorylation • cell differentiation • positive regulation of cell migration • positive regulation of vascular endothelial growth factor receptor signaling pathway • cellular response to vascular endothelial growth factor stimulus • vascular endothelial growth factor receptor-1 signaling pathway • vascular endothelial growth factor signaling pathway • positive regulation of MAP kinase activity • positive regulation of MAPK cascade • positive regulation of phosphatidylinositol 3-kinase activity • positive regulation of angiogenesis • protein autophosphorylation • vascular endothelial growth factor receptor signaling pathway • blood vessel morphogenesis • embryonic morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2321	14254
Ensembl	ENSG00000102755	ENSMUSG00000029648
UniProt	P17948	P35969
RefSeq (mRNA)	NM_001159920	NM_010228
RefSeq (protein)	NP_001153392	NP_034358
Location (UCSC)	Chr 13: 28.3 – 28.5 Mb	Chr 5: 147.56 – 147.73 Mb
PubMed search

Vascular endothelial growth factor receptor 1 is a protein that in humans is encoded by the FLT1 gene.^[1]

Function

Oncogene FLT belongs to the src gene family and is related to oncogene ROS (MIM 165020). Like other members of this family, it shows tyrosine protein kinase activity that is important for the control of cell proliferation and differentiation. The sequence structure of the FLT gene resembles that of the FMS gene (MIM 164770); hence, Yoshida et al. (1987) proposed the name FLT as an acronym for FMS-like tyrosine kinase.[supplied by OMIM]^[2]

Interactions

FLT1 has been shown to interact with PLCG1^[3] and vascular endothelial growth factor B (VEGF-B).^[4][5]

See also

• VEGF receptors

References

1. Shibuya M, Yamaguchi S, Yamane A, Ikeda T, Tojo A, Matsushime H, Sato M (Apr 1990). "Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family". Oncogene 5 (4): 519–24. PMID 2158038.
2. "Entrez Gene: FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)".
3. Cunningham SA, Arrate MP, Brock TA, Waxham MN (Nov 1997). "Interactions of FLT-1 and KDR with phospholipase C gamma: identification of the phosphotyrosine binding sites". Biochemical and Biophysical Research Communications 240 (3): 635–9. doi:10.1006/bbrc.1997.7719. PMID 9398617.
4. Olofsson B, Korpelainen E, Pepper MS, Mandriota SJ, Aase K, Kumar V, Gunji Y, Jeltsch MM, Shibuya M, Alitalo K, Eriksson U (Sep 1998). "Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells". Proceedings of the National Academy of Sciences of the United States of America 95 (20): 11709–14. doi:10.1073/pnas.95.20.11709. PMC 21705. PMID 9751730.
5. Makinen T, Olofsson B, Karpanen T, Hellman U, Soker S, Klagsbrun M, Eriksson U, Alitalo K (Jul 1999). "Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1". The Journal of Biological Chemistry 274 (30): 21217–22. doi:10.1074/jbc.274.30.21217. PMID 10409677.

Further reading

• Petrova TV, Makinen T, Alitalo K (Nov 1999). "Signaling via vascular endothelial growth factor receptors". Experimental Cell Research 253 (1): 117–30. doi:10.1006/excr.1999.4707. PMID 10579917.
• Sato Y, Kanno S, Oda N, Abe M, Ito M, Shitara K, Shibuya M (May 2000). "Properties of two VEGF receptors, Flt-1 and KDR, in signal transduction". Annals of the New York Academy of Sciences 902 (1): 201–5; discussion 205–7. doi:10.1111/j.1749-6632.2000.tb06314.x. PMID 10865839.
• Boyd AW, Lackmann M (Dec 2001). "Signals from Eph and ephrin proteins: a developmental tool kit". Science's STKE : Signal Transduction Knowledge Environment 2001 (112): RE20. doi:10.1126/stke.2001.112.re20. PMID 11741094.
• Luttun A, Tjwa M, Carmeliet P (Dec 2002). "Placental growth factor (PlGF) and its receptor Flt-1 (VEGFR-1): novel therapeutic targets for angiogenic disorders". Annals of the New York Academy of Sciences 979: 80–93. doi:10.1111/j.1749-6632.2002.tb04870.x. PMID 12543719.
• Maynard SE, Venkatesha S, Thadhani R, Karumanchi SA (May 2005). "Soluble Fms-like tyrosine kinase 1 and endothelial dysfunction in the pathogenesis of preeclampsia". Pediatric Research 57 (5 Pt 2): 1R–7R. doi:10.1203/01.PDR.0000159567.85157.B7. PMID 15817508.
• Shibuya M (2007). "Vascular endothelial growth factor receptor-1 (VEGFR-1/Flt-1): a dual regulator for angiogenesis". Angiogenesis 9 (4): 225–30; discussion 231. doi:10.1007/s10456-006-9055-8. PMID 17109193.
• Widmer M, Villar J, Benigni A, Conde-Agudelo A, Karumanchi SA, Lindheimer M (Jan 2007). "Mapping the theories of preeclampsia and the role of angiogenic factors: a systematic review". Obstetrics and Gynecology 109 (1): 168–80. doi:10.1097/01.AOG.0000249609.04831.7c. PMID 17197602.
• López-Novoa JM (Mar 2007). "Soluble endoglin is an accurate predictor and a pathogenic molecule in pre-eclampsia". Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association 22 (3): 712–4. doi:10.1093/ndt/gfl768. PMID 17210583.
• Poesen K, Lambrechts D, Van Damme P, Dhondt J, Bender F, Frank N, Bogaert E, Claes B, Heylen L, Verheyen A, Raes K, Tjwa M, Eriksson U, Shibuya M, Nuydens R, Van Den Bosch L, Meert T, D'Hooge R, Sendtner M, Robberecht W, Carmeliet P (Oct 2008). "Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its ligand VEGF-B in motor neuron degeneration". The Journal of Neuroscience 28 (42): 10451–9. doi:10.1523/JNEUROSCI.1092-08.2008. PMID 18923022.
• Joukov V, Kaipainen A, Jeltsch M, Pajusola K, Olofsson B, Kumar V, Eriksson U, Alitalo K (Nov 1997). "Vascular endothelial growth factors VEGF-B and VEGF-C". Journal of Cellular Physiology 173 (2): 211–5. doi:10.1002/(SICI)1097-4652(199711)173:2<211::AID-JCP23>3.0.CO;2-H. PMID 9365524.
• Kaplan RN, Riba RD, Zacharoulis S, Bramley AH, Vincent L, Costa C, MacDonald DD, Jin DK, Shido K, Kerns SA, Zhu Z, Hicklin D, Wu Y, Port JL, Altorki N, Port ER, Ruggero D, Shmelkov SV, Jensen KK, Rafii S, Lyden D (Dec 2005). "VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche". Nature 438 (7069): 820–7. doi:10.1038/nature04186. PMC 2945882. PMID 16341007.