Gem-associated protein 6

Gem (nuclear organelle) associated protein 6
PDB rendering based on 1y96.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1Y96​
Identifiers
Symbols	GEMIN6 ; FLJ23459
External IDs	OMIM: 607006 MGI: 1914492 HomoloGene: 11711 GeneCards: GEMIN6 Gene
Gene ontology Molecular function • protein binding Cellular component • nucleoplasm • cytoplasm • cytosol • nuclear body • SMN complex • SMN-Sm protein complex • Gemini of coiled bodies Biological process • spliceosomal complex assembly • spliceosomal snRNP assembly • mRNA splicing, via spliceosome • gene expression • ncRNA metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	79833	67242
Ensembl	ENSG00000152147	ENSMUSG00000055760
UniProt	Q8WXD5	Q9CX53
RefSeq (mRNA)	NM_024775	NM_026053
RefSeq (protein)	NP_079051	NP_080329
Location (UCSC)	Chr 2: 38.75 – 38.79 Mb	Chr 17: 80.22 – 80.23 Mb
PubMed search

Gem-associated protein 6 is a protein that in humans is encoded by the GEMIN6 gene.^[1][2]

Function

GEMIN6 is part of a large macromolecular complex, localized to both the cytoplasm and the nucleus, that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), GEMIN4 (MIM 606969), and GEMIN5 (MIM 607005).[supplied by OMIM]^[2]

Interactions

Gem-associated protein 6 has been shown to interact with Gem-associated protein 7.^[3][4]

References

1. Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G (Mar 2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". The Journal of Biological Chemistry 277 (9): 7540–5. doi:10.1074/jbc.M110141200. PMID 11748230.
2. "Entrez Gene: GEMIN6 gem (nuclear organelle) associated protein 6".
3. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
4. Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (Aug 2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". The Journal of Biological Chemistry 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586.

Further reading

• Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (Aug 2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". The Journal of Biological Chemistry 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586.
• Ma Y, Dostie J, Dreyfuss G, Van Duyne GD (Jun 2005). "The Gemin6-Gemin7 heterodimer from the survival of motor neurons complex has an Sm protein-like structure". Structure 13 (6): 883–92. doi:10.1016/j.str.2005.03.014. PMID 15939020.
• Carissimi C, Saieva L, Gabanella F, Pellizzoni L (Dec 2006). "Gemin8 is required for the architecture and function of the survival motor neuron complex". The Journal of Biological Chemistry 281 (48): 37009–16. doi:10.1074/jbc.M607505200. PMID 17023415.