SMC2

Structural maintenance of chromosomes 2
Identifiers
Symbols	SMC2 ; CAP-E; CAPE; SMC-2; SMC2L1
External IDs	OMIM: 605576 MGI: 106067 HomoloGene: 4705 GeneCards: SMC2 Gene
Gene ontology Molecular function • protein binding • ATP binding • protein heterodimerization activity Cellular component • nuclear chromosome • condensed chromosome • condensin complex • nucleus • nucleoplasm • cytoplasm • cytosol • extracellular exosome Biological process • mitotic cell cycle • mitotic chromosome condensation • meiotic chromosome condensation • meiotic chromosome segregation • cell division • kinetochore organization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10592	14211
Ensembl	ENSG00000136824	ENSMUSG00000028312
UniProt	O95347	Q8CG48
RefSeq (mRNA)	NM_001042550	NM_001301412
RefSeq (protein)	NP_001036015	NP_001288341
Location (UCSC)	Chr 9: 104.09 – 104.14 Mb	Chr 4: 52.44 – 52.49 Mb
PubMed search

Structural maintenance of chromosomes protein 2 (SMC-2) also known as chromosome-associated protein E (CAP-E) is a protein that in humans is encoded by the SMC2 gene.^[1][2]

SMC-2 is a subunit of condensin I and II, large protein complexes involved in chromosome condensation.

Interactions

SMC2 has been shown to interact with DNMT3B.^[3]

References

1. Schmiesing JA, Ball AR, Gregson HC, Alderton JM, Zhou S, Yokomori K (Oct 1998). "Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics". Proceedings of the National Academy of Sciences of the United States of America 95 (22): 12906–11. doi:10.1073/pnas.95.22.12906. PMC 23650. PMID 9789013.
2. "Entrez Gene: SMC2 structural maintenance of chromosomes 2".
3. Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, Heale JT, Schmiesing JA, Kim W, Yokomori K, Zhao Y, Robertson KD (2004). "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery". Nucleic Acids Research 32 (9): 2716–29. doi:10.1093/nar/gkh589. PMC 419596. PMID 15148359.

Further reading

• Ham MF, Takakuwa T, Rahadiani N, Tresnasari K, Nakajima H, Aozasa K (Jul 2007). "Condensin mutations and abnormal chromosomal structures in pyothorax-associated lymphoma". Cancer Science 98 (7): 1041–7. doi:10.1111/j.1349-7006.2007.00500.x. PMID 17488335.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (Jan 2005). "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, Heale JT, Schmiesing JA, Kim W, Yokomori K, Zhao Y, Robertson KD (2004). "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery". Nucleic Acids Research 32 (9): 2716–29. doi:10.1093/nar/gkh589. PMC 419596. PMID 15148359.
• Przewloka MR, Pardington PE, Yannone SM, Chen DJ, Cary RB (Feb 2003). "In vitro and in vivo interactions of DNA ligase IV with a subunit of the condensin complex". Molecular Biology of the Cell 14 (2): 685–97. doi:10.1091/mbc.E01-11-0117. PMC 150001. PMID 12589063.
• Kimura K, Cuvier O, Hirano T (Feb 2001). "Chromosome condensation by a human condensin complex in Xenopus egg extracts". The Journal of Biological Chemistry 276 (8): 5417–20. doi:10.1074/jbc.C000873200. PMID 11136719.
• Schmiesing JA, Gregson HC, Zhou S, Yokomori K (Sep 2000). "A human condensin complex containing hCAP-C-hCAP-E and CNAP1, a homolog of Xenopus XCAP-D2, colocalizes with phosphorylated histone H3 during the early stage of mitotic chromosome condensation". Molecular and Cellular Biology 20 (18): 6996–7006. doi:10.1128/MCB.20.18.6996-7006.2000. PMC 88774. PMID 10958694.