TNP1

Transition protein 1 (during histone to protamine replacement)
Identifiers
Symbols	TNP1 ; TP1
External IDs	OMIM: 190231 MGI: 98784 HomoloGene: 136517 GeneCards: TNP1 Gene
Gene ontology Molecular function • DNA binding • protein binding Cellular component • nucleosome • male germ cell nucleus Biological process • single strand break repair • nucleosome disassembly • chromatin remodeling • chromatin silencing • multicellular organismal development • spermatid development • spermatid nucleus differentiation • spermatid nucleus elongation • sexual reproduction • sperm motility • fertilization, exchange of chromosomal proteins • negative regulation of transcription, DNA-templated Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7141	21958
Ensembl	ENSG00000118245	ENSMUSG00000026182
UniProt	P09430	P10856
RefSeq (mRNA)	NM_003284	NM_009407
RefSeq (protein)	NP_003275	NP_033433
Location (UCSC)	Chr 2: 216.86 – 216.86 Mb	Chr 1: 73.02 – 73.02 Mb
PubMed search

Spermatid nuclear transition protein 1 is a protein that in humans is encoded by the TNP1 gene.^[1][2]

References

1. Luerssen H, Mattei MG, Schroter M, Grzeschik KH, Adham IM, Engel W (Jan 1991). "Nucleotide sequence of the gene for human transition protein 1 and its chromosomal localization on chromosome 2". Genomics 8 (2): 324–30. doi:10.1016/0888-7543(90)90289-7. PMID 2249851.
2. "Entrez Gene: TNP1 transition protein 1 (during histone to protamine replacement)".

Further reading

• Meistrich ML, Mohapatra B, Shirley CR, Zhao M (2004). "Roles of transition nuclear proteins in spermiogenesis.". Chromosoma 111 (8): 483–8. doi:10.1007/s00412-002-0227-z. PMID 12743712.
• Chirat F, Martinage A, Briand G, et al. (1991). "Nuclear transition protein 1 from ram elongating spermatids. Mass spectrometric characterization, primary structure and phosphorylation sites of two variants.". Eur. J. Biochem. 198 (1): 13–20. doi:10.1111/j.1432-1033.1991.tb15980.x. PMID 2040274.
• Baskaran R, Rao MR (1991). "Interaction of spermatid-specific protein TP2 with nucleic acids, in vitro. A comparative study with TP1.". J. Biol. Chem. 265 (34): 21039–47. PMID 2250010.
• Kleene KC, Borzorgzadeh A, Flynn JF, et al. (1988). "Nucleotide sequence of a cDNA clone encoding mouse transition protein 1.". Biochim. Biophys. Acta 950 (2): 215–20. doi:10.1016/0167-4781(88)90013-9. PMID 3382664.
• Luerssen H, Hoyer-Fender S, Engel W (1988). "The nucleotide sequence of human transition protein 1 cDNA.". Nucleic Acids Res. 16 (15): 7723. doi:10.1093/nar/16.15.7723. PMC 338445. PMID 3412903.
• Akama K, Kojima S, Nakano M, et al. (1994). "The amino acid sequence and phosphorylation sites of a boar transition protein 1.". Biochem. Mol. Biol. Int. 32 (2): 349–57. PMID 8019440.
• Steger K, Klonisch T, Gavenis K, et al. (1999). "Expression of mRNA and protein of nucleoproteins during human spermiogenesis.". Mol. Hum. Reprod. 4 (10): 939–45. doi:10.1093/molehr/4.10.939. PMID 9809674.
• Yu YE, Zhang Y, Unni E, et al. (2000). "Abnormal spermatogenesis and reduced fertility in transition nuclear protein 1-deficient mice.". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4683–8. doi:10.1073/pnas.97.9.4683. PMC 18293. PMID 10781074.
• Siffroi JP, Alfonsi MF, Dadoune JP (2001). "Electron microscopic in situ hybridization study of simultaneous expression of TNP1 and PRM1 genes in human spermatids.". Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia 103 (4 Suppl 1): 65–74. PMID 11315969.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Miyagawa Y, Nishimura H, Tsujimura A, et al. (2006). "Single-nucleotide polymorphisms and mutation analyses of the TNP1 and TNP2 genes of fertile and infertile human male populations.". J. Androl. 26 (6): 779–86. doi:10.2164/jandrol.05069. PMID 16291974.
• Jedrzejczak P, Kempisty B, Bryja A, et al. (2007). "Quantitative assessment of transition proteins 1, 2 spermatid-specific linker histone H1-like protein transcripts in spermatozoa from normozoospermic and asthenozoospermic men.". Arch. Androl. 53 (4): 199–205. doi:10.1080/01485010701426430. PMID 17852044.