SMC5

Structural maintenance of chromosomes 5
Identifiers
Symbols	SMC5 ; SMC5L1
External IDs	OMIM: 609386 MGI: 2385088 HomoloGene: 41009 GeneCards: SMC5 Gene
Gene ontology Molecular function • protein binding • ATP binding Cellular component • chromosome, telomeric region • nucleus • nucleoplasm • PML body • cell junction • Smc5-Smc6 complex Biological process • telomere maintenance via recombination • double-strand break repair via homologous recombination • double-strand break repair via nonhomologous end joining • mitotic nuclear division • protein sumoylation • positive regulation of maintenance of mitotic sister chromatid cohesion • post-translational protein modification • cellular protein metabolic process • positive regulation of mitotic metaphase/anaphase transition • cell division • cellular senescence Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23137	226026
Ensembl	ENSG00000198887	ENSMUSG00000024943
UniProt	Q8IY18	Q8CG46
RefSeq (mRNA)	NM_015110	NM_001252684
RefSeq (protein)	NP_055925	NP_001239613
Location (UCSC)	Chr 9: 70.26 – 70.35 Mb	Chr 19: 23.21 – 23.27 Mb
PubMed search

Structural maintenance of chromosomes protein 5 is a protein encoded by the SMC5 gene in human.^[1][2]

It is involved in the Alternative lengthening of telomeres cancer mechanism.^[3]

References

1. Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Aug 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
2. "Entrez Gene: SMC5 structural maintenance of chromosomes 5".
3. Potts PR, Yu H (2007). "The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins". Nat. Struct. Mol. Biol. 14 (7): 581–90. doi:10.1038/nsmb1259. PMID 17589526.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Taylor EM, Moghraby JS, Lees JH, et al. (2001). "Characterization of a Novel Human SMC Heterodimer Homologous to the Schizosaccharomyces pombe Rad18/Spr18 Complex". Mol. Biol. Cell 12 (6): 1583–94. doi:10.1091/mbc.12.6.1583. PMC 37326. PMID 11408570.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Potts PR, Yu H (2005). "Human MMS21/NSE2 Is a SUMO Ligase Required for DNA Repair". Mol. Cell. Biol. 25 (16): 7021–32. doi:10.1128/MCB.25.16.7021-7032.2005. PMC 1190242. PMID 16055714.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Potts PR, Porteus MH, Yu H (2006). "Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks". EMBO J. 25 (14): 3377–88. doi:10.1038/sj.emboj.7601218. PMC 1523187. PMID 16810316.