IL36B

Interleukin 36, beta
Identifiers
Symbols	IL36B ; FIL1; FIL1-(ETA); FIL1H; FILI-(ETA); IL-1F8; IL-1H2; IL1-ETA; IL1F8; IL1H2
External IDs	OMIM: 605508 MGI: 1916927 HomoloGene: 18278 GeneCards: IL36B Gene
Gene ontology Molecular function • cytokine activity • interleukin-1 receptor binding Cellular component • extracellular region • extracellular space Biological process • inflammatory response to antigenic stimulus • immune response • cytokine-mediated signaling pathway • positive regulation of interleukin-6 production • innate immune response • positive regulation of T cell differentiation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	27177	69677
Ensembl	ENSG00000136696	ENSMUSG00000026985
UniProt	Q9NZH7	Q9D6Z6
RefSeq (mRNA)	NM_014438	NM_027163
RefSeq (protein)	NP_055253	NP_081439
Location (UCSC)	Chr 2: 113.02 – 113.05 Mb	Chr 2: 24.15 – 24.16 Mb
PubMed search

Interleukin-36 beta also known as interleukin-1 family member 8 (IL1F8) is a protein that in humans is encoded by the IL36B gene.^[1][2][3][4]

Function

The protein encoded by this gene is a member of the interleukin 1 cytokine family. Protein structure modeling indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.^[4]

References

1. Smith DE, Renshaw BR, Ketchem RR, Kubin M, Garka KE, Sims JE (Feb 2000). "Four new members expand the interleukin-1 superfamily". J Biol Chem 275 (2): 1169–75. doi:10.1074/jbc.275.2.1169. PMID 10625660.
2. Mulero JJ, Pace AM, Nelken ST, Loeb DB, Correa TR, Drmanac R, Ford JE (Nov 1999). "IL1HY1: A novel interleukin-1 receptor antagonist gene". Biochem Biophys Res Commun 263 (3): 702–6. doi:10.1006/bbrc.1999.1440. PMID 10512743.
3. Magne D, Palmer G, Barton JL, Mezin F, Talabot-Ayer D, Bas S, Duffy T, Noger M, Guerne PA, Nicklin MJ, Gabay C (Jun 2006). "The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes". Arthritis Research & Therapy 8 (3): R80. doi:10.1186/ar1946. PMC 1526623. PMID 16646978.
4. "Entrez Gene: IL1F8 interleukin 1 family, member 8 (eta)".

Further reading

• Nicklin MJ, Weith A, Duff GW (1994). "A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes". Genomics 19 (2): 382–4. doi:10.1006/geno.1994.1076. PMID 8188271.
• Nothwang HG, Strahm B, Denich D, et al. (1997). "Molecular cloning of the interleukin-1 gene cluster: construction of an integrated YAC/PAC contig and a partial transcriptional map in the region of chromosome 2q13". Genomics 41 (3): 370–8. doi:10.1006/geno.1997.4654. PMID 9169134.
• Kumar S, McDonnell PC, Lehr R, et al. (2000). "Identification and initial characterization of four novel members of the interleukin-1 family". J. Biol. Chem. 275 (14): 10308–14. doi:10.1074/jbc.275.14.10308. PMID 10744718.
• Busfield SJ, Comrack CA, Yu G, et al. (2000). "Identification and gene organization of three novel members of the IL-1 family on human chromosome 2". Genomics 66 (2): 213–6. doi:10.1006/geno.2000.6184. PMID 10860666.
• Barton JL, Herbst R, Bosisio D, et al. (2001). "A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities". Eur. J. Immunol. 30 (11): 3299–308. doi:10.1002/1521-4141(200011)30:11<3299::AID-IMMU3299>3.0.CO;2-S. PMID 11093146.
• Pan G, Risser P, Mao W, et al. (2001). "IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp". Cytokine 13 (1): 1–7. doi:10.1006/cyto.2000.0799. PMID 11145836.
• Lin H, Ho AS, Haley-Vicente D, et al. (2001). "Cloning and characterization of IL-1HY2, a novel interleukin-1 family member". J. Biol. Chem. 276 (23): 20597–602. doi:10.1074/jbc.M010095200. PMID 11278614.
• Debets R, Timans JC, Homey B, et al. (2001). "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2". J. Immunol. 167 (3): 1440–6. doi:10.4049/jimmunol.167.3.1440. PMID 11466363.
• Sims JE, Nicklin MJ, Bazan JF, et al. (2001). "A new nomenclature for IL-1-family genes". Trends Immunol. 22 (10): 536–7. doi:10.1016/S1471-4906(01)02040-3. PMID 11574262.
• Nicklin MJ, Barton JL, Nguyen M, et al. (2002). "A sequence-based map of the nine genes of the human interleukin-1 cluster". Genomics 79 (5): 718–25. doi:10.1006/geno.2002.6751. PMID 11991722.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Towne JE, Garka KE, Renshaw BR, et al. (2004). "Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs". J. Biol. Chem. 279 (14): 13677–88. doi:10.1074/jbc.M400117200. PMID 14734551.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.