Interleukin 24

Interleukin 24
Identifiers
Symbols	IL24 ; C49A; FISP; IL10B; MDA7; MOB5; ST16
External IDs	OMIM: 604136 MGI: 2135548 HomoloGene: 4991 GeneCards: IL24 Gene
Gene ontology Molecular function • cytokine activity • protein binding Cellular component • extracellular space Biological process • apoptotic process • inflammatory response • immune response • positive regulation of cell proliferation • negative regulation of cell proliferation • negative regulation of cell migration • serine phosphorylation of STAT3 protein • wound healing • positive regulation of tyrosine phosphorylation of Stat3 protein • positive regulation of JAK-STAT cascade • cellular response to lipopolysaccharide • cellular response to interleukin-4 Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11009	93672
Ensembl	ENSG00000162892	ENSMUSG00000026420
UniProt	Q13007	Q925S4
RefSeq (mRNA)	NM_001185156	NM_053095
RefSeq (protein)	NP_001172085	NP_444325
Location (UCSC)	Chr 1: 206.9 – 206.9 Mb	Chr 1: 130.88 – 130.89 Mb
PubMed search

Interleukin 24 (IL-24) is a protein that in humans is encoded by the IL24 gene.

IL-24 is a cytokine belonging to the IL-10 family of cytokines that signals through two heterodimeric receptors: IL-20R1/IL-20R2 and IL-22R1/IL-20R2. This interleukin is also known as melanoma differentiation-associated 7 (mda-7) due to its discovery as a tumour suppressing protein. IL-24 appears to control in cell survival and proliferation by inducing rapid activation of particular transcription factors called STAT1 and STAT3. This cytokine is predominantly released by activated monocytes, macrophages and T helper 2 (Th2) cells^[1] and acts on non-haematopoietic tissues such as skin, lung and reproductive tissues. IL-24 performs important roles in wound healing, psoriasis and cancer.^[2] Several studies have shown that cell death occurs in cancer cells/cell lines following exposure to IL-24.^[3][4] The gene for IL-24 is located on chromosome 1 in humans.^[5]

References

1. Poindexter NJ, Walch ET, Chada S, Grimm EA (September 2005). "Cytokine induction of interleukin-24 in human peripheral blood mononuclear cells". J. Leukoc. Biol. 78 (3): 745–52. doi:10.1189/jlb.0205116. PMID 16000394.
2. Wang M, Liang P (February 2005). "Interleukin-24 and its receptors". Immunology 114 (2): 166–70. doi:10.1111/j.1365-2567.2005.02094.x. PMC 1782067. PMID 15667561.
3. Fisher PB, Gopalkrishnan RV, Chada S, Ramesh R, Grimm EA, Rosenfeld MR, Curiel DT, Dent P (2003). "mda-7/IL-24, a novel cancer selective apoptosis inducing cytokine gene: from the laboratory into the clinic". Cancer Biol. Ther. 2 (4 Suppl 1): S23–37. PMID 14508078.
4. Sauane M, Lebedeva IV, Su ZZ, Choo HT, Randolph A, Valerie K, Dent P, Gopalkrishnan RV, Fisher PB (May 2004). "Melanoma differentiation associated gene-7/interleukin-24 promotes tumor cell-specific apoptosis through both secretory and nonsecretory pathways". Cancer Res. 64 (9): 2988–93. doi:10.1158/0008-5472.CAN-04-0200. PMID 15126330.
5. IL24 GeneCard

External links

Interleukin24 bibliography of open articles and PubMed search term