Interleukin 32
| Interleukin 32 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | IL32 ; IL-32alpha; IL-32beta; IL-32delta; IL-32gamma; NK4; TAIF; TAIFa; TAIFb; TAIFc; TAIFd | ||||||||||||
| External IDs | OMIM: 606001 HomoloGene: 128400 GeneCards: IL32 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 9235 | n/a | |||||||||||
| Ensembl | ENSG00000008517 | n/a | |||||||||||
| UniProt | P24001 | n/a | |||||||||||
| RefSeq (mRNA) | NM_001012631 | n/a | |||||||||||
| RefSeq (protein) | NP_001012649 | n/a | |||||||||||
| Location (UCSC) |
Chr 16: 3.07 – 3.08 Mb | n/a | |||||||||||
| PubMed search | n/a | ||||||||||||
Interleukin 32 (Il32) is a protein that in humans is encoded by the IL32 gene.[1]
Function
This gene encodes a member of the cytokine family. The protein contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression of this protein is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. This protein induces the production of TNF-alpha from macrophage cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[1]
Interleukin 32 (IL-32) is a pro-inflammatory cytokine that can induce cells of the immune system (such as monocytes and macrophages) to secrete inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and IL-6. In addition, it can also induce the production of chemokines such as IL-8 and MIP-2 / CXCL2.[2]
IL-32 can also support osteoclast differentiation but not osteoclast activation by regulating the MAPK/ERK pathway and the actin cytoskeleton.[3]
References
- 1 2 "Entrez Gene: Interleukin 32".
- ↑ Kim SH, Han SY, Azam T, Yoon DY, Dinarello CA (January 2005). "Interleukin-32: a cytokine and inducer of TNFalpha". Immunity 22 (1): 131–42. doi:10.1016/j.immuni.2004.12.003. PMID 15664165.
- ↑ Mabilleau G, Sabokbar A (2009). "Interleukin-32 promotes osteoclast differentiation but not osteoclast activation". PLoS ONE 4 (1): e4173. doi:10.1371/journal.pone.0004173. PMC 2613539. PMID 19137064.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.