Interleukin 30

Interleukin 27
Identifiers
Symbols	IL27 ; IL-27; IL-27A; IL27A; IL27p28; IL30; p28
External IDs	OMIM: 608273 HomoloGene: 17087 GeneCards: IL27 Gene
Gene ontology Molecular function • receptor binding • cytokine activity • interleukin-27 receptor binding Cellular component • extracellular space Biological process • inflammatory response • response to bacterium • regulation of T cell proliferation • positive regulation of interferon-gamma biosynthetic process • innate immune response • regulation of T-helper 1 cell differentiation • regulation of defense response to virus Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	246778	246779
Ensembl	ENSG00000197272	ENSMUSG00000044701
UniProt	Q8NEV9	Q8K3I6
RefSeq (mRNA)	NM_145659	NM_145636
RefSeq (protein)	NP_663634	NP_663611
Location (UCSC)	Chr 16: 28.5 – 28.51 Mb	Chr 7: 126.59 – 126.59 Mb
PubMed search

Interleukin-30 (IL-30) is a protein with a molecular weight of 28 kilodaltons, which forms one chain of the heterodimeric cytokine called interleukin 27 (IL-27), thus is sometimes called IL27-p28. The other chain of IL-27 is a molecule called Epstein-Barr induced gene-3 (EBI3). IL-30 is a member of the long-chain, 4-helix bundle family of cytokines, making it structurally similar to IL-6.^[1] This gene for this molecule is now officially called IL-27 under HGNC guidelines.^[2]

References

1. Pflanz S, Timans JC, Cheung J, Rosales R, Kanzler H, Gilbert J, Hibbert L, Churakova T, Travis M, Vaisberg E, Blumenschein WM, Mattson JD, Wagner JL, To W, Zurawski S, McClanahan TK, Gorman DM, Bazan JF, de Waal Malefyt R, Rennick D, Kastelein RA (June 2002). "IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells". Immunity 16 (6): 779–90. doi:10.1016/S1074-7613(02)00324-2. PMID 12121660.
2. http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=19157