Interleukin 20

Interleukin 20
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4DOH​
Identifiers
Symbols	IL20 ; IL-20; IL10D; ZCYTO10
External IDs	OMIM: 605619 HomoloGene: 10286 GeneCards: IL20 Gene
Gene ontology Molecular function • cytokine activity • interleukin-20 receptor binding • interleukin-22 receptor binding Cellular component • extracellular region • extracellular space Biological process • inflammatory response • immune response • positive regulation of tyrosine phosphorylation of Stat3 protein • positive regulation of epidermal cell differentiation • positive regulation of keratinocyte differentiation • positive regulation of osteoclast differentiation • regulation of inflammatory response Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	50604	58181
Ensembl	ENSG00000162891	ENSMUSG00000026416
UniProt	Q9NYY1	Q9JKV9
RefSeq (mRNA)	NM_018724	NM_021380
RefSeq (protein)	NP_061194	NP_067355
Location (UCSC)	Chr 1: 206.87 – 206.87 Mb	Chr 1: 130.91 – 130.91 Mb
PubMed search

Interleukin 20 (IL20) is a protein that in humans is encoded by the IL20 gene.^[1] Interkeukin 20 also includes other cytokines, including IL-19, IL-20, IL-22, IL-24, and IL-26. Based on common structural and functional properties of IL-20's receptors and target cells, these cytokines constitute the same subfamily, IL-20.^[2]

Function

The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL-10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis.^[1]

Interleukin-20 (IL-20) is a protein belonging to the IL-10 family of cytokines. IL-20 is produced by activated keratinocytes and monocytes and transmits an intracellular signal through two distinct cell-surface receptor complexes on keratinocytes and other epithelial cells. IL-20 regulates proliferation and differentiation of keratinocytes during inflammation, particularly inflammation associated with the skin. In addition, IL-20 also causes cell expansion of multipotential hematopoietic progenitor cells.^[3]

Anti IL-20

Anti-IL-20 monoclonal antibodies have been researched as clinical candidates for the treatment or prevention of psoriasis, rheumatoid arthritis, atherosclerosis, osteoporosis, and stroke.^[4][5]

References

1. "Entrez Gene: Interleukin 20".
2. Rutz S, Wang X, Ouyang W (Dec 2014). "The IL-20 subfamily of cytokines--from host defence to tissue homeostasis". Nature Reviews. Immunology 14 (12): 783–95. doi:10.1038/nri3766. PMID 25421700.
3. Rich BE, Kupper TS (August 2006). "Interleukin 20". Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 5 (3): 243–250. doi:10.2174/187152306778017683.
4. Kragstrup TW, Otkjaer K, Holm C, Jørgensen A, Hokland M, Iversen L, Deleuran B (Jan 2008). "The expression of IL-20 and IL-24 and their shared receptors are increased in rheumatoid arthritis and spondyloarthropathy". Cytokine 41 (1): 16–23. doi:10.1016/j.cyto.2007.10.004. PMID 18061474.
5. Hsu YH, Chen WY, Chan CH, Wu CH, Sun ZJ, Chang MS (Aug 2011). "Anti-IL-20 monoclonal antibody inhibits the differentiation of osteoclasts and protects against osteoporotic bone loss". The Journal of Experimental Medicine 208 (9): 1849–61. doi:10.1084/jem.20102234. PMID 21844205.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.