JWH-148

JWH-148

Systematic (IUPAC) name
(4-methyl-1-naphthalenyl)(2-methyl-1-propyl-1H-indol-3-yl)methanone
Identifiers
CAS Number	824955-99-9
PubChem	CID 45267819
ChemSpider	24627234
Chemical data
Formula	C24H23NO
Molar mass	341.45 g/mol
SMILES CCCN1C(=C(C2=CC=CC=C21)C(=O)C3=CC=C(C4=CC=CC=C43)C)C
InChI InChI=1S/C24H23NO/c1-4-15-25-17(3)23(21-11-7-8-12-22(21)25)24(26)20-14-13-16(2)18-9-5-6-10-19(18)20/h5-14H,4,15H2,1-3H3 Key:WRIOMNWYCFMMEY-UHFFFAOYSA-N

JWH-148 is a synthetic cannabimimetic that was discovered by John W. Huffman. It is the indole 2-methyl analog of JWH-120. It is a moderately selective ligand for the CB₂ receptor, with a binding affinity of K_i = 14.0 ± 1.0 nM at this subtype, and more than 8 times selectivity over the CB₁ subtype.^[1]

See also

• JWH-120
• JWH-122
• JWH-193
• JWH-210
• JWH-398

References

1. Huffman, J.; et al. (2005). "Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists.". Bioorganic & Medicinal Chemistry 13 (1): 89–112. doi:10.1016/j.bmc.2004.09.050. PMID 15582455.