OR2A12

Olfactory receptor, family 2, subfamily A, member 12
Identifiers
Symbols	OR2A12 ; OR2A12P; OR2A16P
External IDs	MGI: 3030280 HomoloGene: 17179 GeneCards: OR2A12 Gene
Gene ontology Molecular function • G-protein coupled receptor activity • olfactory receptor activity Cellular component • plasma membrane • integral component of membrane Biological process • G-protein coupled receptor signaling pathway • sensory perception of smell • detection of chemical stimulus involved in sensory perception of smell Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	346525	258292
Ensembl	ENSG00000221858	ENSMUSG00000073111
UniProt	Q8NGT7	Q8VEV0
RefSeq (mRNA)	NM_001004135	NM_146295
RefSeq (protein)	NP_001004135	NP_666407
Location (UCSC)	Chr 7: 144.1 – 144.1 Mb	Chr 6: 42.93 – 42.93 Mb
PubMed search

Olfactory receptor 2A12 is a protein that in humans is encoded by the OR2A12 gene.^[1]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.^[1]

See also

• Olfactory receptor

References

1. "Entrez Gene: OR2A12 olfactory receptor, family 2, subfamily A, member 12".

Further reading

• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes.". Genomics 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
• Gilad Y, Lancet D (2003). "Population differences in the human functional olfactory repertoire.". Mol. Biol. Evol. 20 (3): 307–14. doi:10.1093/molbev/msg013. PMID 12644552.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family.". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

• OR2A12 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.