OR4E2

Olfactory receptor, family 4, subfamily E, member 2
Identifiers
Symbols	OR4E2 ; OR14-42
External IDs	MGI: 3031343 HomoloGene: 41378 GeneCards: OR4E2 Gene
Gene ontology Molecular function • transmembrane signaling receptor activity • G-protein coupled receptor activity • olfactory receptor activity Cellular component • plasma membrane • integral component of membrane Biological process • G-protein coupled receptor signaling pathway • detection of chemical stimulus involved in sensory perception • detection of chemical stimulus involved in sensory perception of smell Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	26686	57271
Ensembl	ENSG00000221977	ENSMUSG00000035626
UniProt	Q8NGC2	Q7TQQ0
RefSeq (mRNA)	NM_001001912	NM_020514
RefSeq (protein)	NP_001001912	NP_065260
Location (UCSC)	Chr 14: 21.67 – 21.67 Mb	Chr 14: 52.45 – 52.45 Mb
PubMed search

Olfactory receptor 4E2 is a protein that in humans is encoded by the OR4E2 gene.^[1]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.^[1]

See also

• Olfactory receptor

References

1. "Entrez Gene: OR4E2 olfactory receptor, family 4, subfamily E, member 2".

Further reading

• Koop BF, Rowen L, Wang K, et al. (1994). "The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA.". Genomics 19 (3): 478–93. doi:10.1006/geno.1994.1097. PMID 8188290.
• Boysen C, Simon MI, Hood L (1997). "Analysis of the 1.1-Mb human alpha/delta T-cell receptor locus with bacterial artificial chromosome clones.". Genome Res. 7 (4): 330–8. doi:10.1101/gr.7.4.330. PMID 9110172.
• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes.". Genomics 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family.". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

• OR4E2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.