OR2K2

Olfactory receptor, family 2, subfamily K, member 2
Identifiers
Symbols	OR2K2 ; HSHTPCRH06; HTPCRH06; OR2AN1P; OR2AR1P
External IDs	MGI: 3030101 HomoloGene: 17436 GeneCards: OR2K2 Gene
Gene ontology Molecular function • G-protein coupled receptor activity • olfactory receptor activity Cellular component • plasma membrane • integral component of membrane Biological process • G-protein coupled receptor signaling pathway • sensory perception of smell • detection of chemical stimulus involved in sensory perception of smell Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	26248	258922
Ensembl	ENSG00000171133	ENSMUSG00000043385
UniProt	Q8NGT1	A2AM35
RefSeq (mRNA)	NM_205859	NM_146920
RefSeq (protein)	NP_995581	NP_667131
Location (UCSC)	Chr 9: 111.33 – 111.33 Mb	Chr 4: 58.78 – 58.79 Mb
PubMed search

Olfactory receptor 2K2 is a protein that in humans is encoded by the OR2K2 gene.^[1][2][3]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.^[3]

See also

• Olfactory receptor

References

1. Parmentier M, Libert F, Schurmans S, Schiffmann S, Lefort A, Eggerickx D, Ledent C, Mollereau C, Gerard C, Perret J; et al. (Mar 1992). "Expression of members of the putative olfactory receptor gene family in mammalian germ cells". Nature 355 (6359): 453–5. doi:10.1038/355453a0. PMID 1370859.
2. Aloni R, Olender T, Lancet D (Jan 2007). "Ancient genomic architecture for mammalian olfactory receptor clusters". Genome Biol 7 (10): R88. doi:10.1186/gb-2006-7-10-r88. PMC 1794568. PMID 17010214.
3. "Entrez Gene: OR2K2 olfactory receptor, family 2, subfamily K, member 2".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family.". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• OR2K2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.