OR3A4

Olfactory receptor, family 3, subfamily A, member 4 pseudogene
Identifiers
Symbols	OR3A4P ; OLFRA05; OLFRA06; OR17-13; OR17-16; OR17-24; OR17-25; OR24; OR25; OR3A4; OR3A5P
External IDs	MGI: 3030233 HomoloGene: 27325 GeneCards: OR3A4P Gene
Gene ontology Molecular function • receptor activity • olfactory receptor activity Cellular component • membrane • integral to membrane Biological process • signal transduction • G-protein coupled receptor protein signaling pathway • sensory perception of smell • response to stimulus Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	390756	259006
Ensembl	ENSG00000180068	ENSMUSG00000043692
UniProt	P47883	n/a
RefSeq (mRNA)	NM_001005334	NM_147004
RefSeq (protein)	NP_001005334	NP_667215
Location (UCSC)	Chr 17: 3.21 – 3.22 Mb	Chr 11: 73.87 – 73.87 Mb
PubMed search

Olfactory receptor 3A4 is a protein that in humans is encoded by the OR3A4 gene.^[1]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.^[1]

See also

• Olfactory receptor

References

1. "Entrez Gene: OR3A4 olfactory receptor, family 3, subfamily A, member 4".

Further reading

• Ben-Arie N, Lancet D, Taylor C, et al. (1994). "Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire". Hum. Mol. Genet. 3 (2): 229–35. doi:10.1093/hmg/3.2.229. PMID 8004088.
• Glusman G, Clifton S, Roe B, Lancet D (1997). "Sequence analysis in the olfactory receptor gene cluster on human chromosome 17: recombinatorial events affecting receptor diversity". Genomics 37 (2): 147–60. doi:10.1006/geno.1996.0536. PMID 8921386.
• Glusman G, Sosinsky A, Ben-Asher E, et al. (2000). "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster". Genomics 63 (2): 227–45. doi:10.1006/geno.1999.6030. PMID 10673334.
• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

• OR3A4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.