OR3A1
| Olfactory receptor, family 3, subfamily A, member 1 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | OR3A1 ; OLFRA03; OR17-40; OR17-82; OR40 | ||||||||||||
| External IDs | MGI: 3030236 HomoloGene: 1915 GeneCards: OR3A1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 4994 | 258703 | |||||||||||
| Ensembl | ENSG00000180090 | ENSMUSG00000070379 | |||||||||||
| UniProt | P47881 | Q8VFX7 | |||||||||||
| RefSeq (mRNA) | NM_002550 | NM_146708 | |||||||||||
| RefSeq (protein) | NP_002541 | NP_666919 | |||||||||||
| Location (UCSC) |
Chr 17: 3.29 – 3.29 Mb |
Chr 11: 74.16 – 74.16 Mb | |||||||||||
| PubMed search | |||||||||||||
Olfactory receptor 3A1 is a protein that in humans is encoded by the OR3A1 gene.[1][2][3]
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[3]
See also
References
- ↑ Glusman G, Clifton S, Roe B, Lancet D (Feb 1997). "Sequence analysis in the olfactory receptor gene cluster on human chromosome 17: recombinatorial events affecting receptor diversity". Genomics 37 (2): 147–60. doi:10.1006/geno.1996.0536. PMID 8921386.
- ↑ Crowe ML, Perry BN, Connerton IF (Jul 1996). "Olfactory receptor-encoding genes and pseudogenes are expressed in humans". Gene 169 (2): 247–9. doi:10.1016/0378-1119(95)00849-7. PMID 8647456.
- 1 2 "Entrez Gene: OR3A1 olfactory receptor, family 3, subfamily A, member 1".
Further reading
- Marrakchi M, Vidic J, Jaffrezic-Renault N, et al. (2008). "A new concept of olfactory biosensor based on interdigitated microelectrodes and immobilized yeasts expressing the human receptor OR17-40". Eur. Biophys. J. 36 (8): 1015–8. doi:10.1007/s00249-007-0187-6. PMID 17579849.
- Jacquier V, Prummer M, Segura JM, et al. (2006). "Visualizing odorant receptor trafficking in living cells down to the single-molecule level". Proc. Natl. Acad. Sci. U.S.A. 103 (39): 14325–30. doi:10.1073/pnas.0603942103. PMC 1599963. PMID 16980412.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Glusman G, Sosinsky A, Ben-Asher E, et al. (2000). "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster". Genomics 63 (2): 227–45. doi:10.1006/geno.1999.6030. PMID 10673334.
- Ben-Arie N, Lancet D, Taylor C, et al. (1994). "Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire". Hum. Mol. Genet. 3 (2): 229–35. doi:10.1093/hmg/3.2.229. PMID 8004088.
External links
- OR3A1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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