OR2A4

Olfactory receptor, family 2, subfamily A, member 4
Identifiers
Symbols	OR2A4 ; OR2A10
External IDs	MGI: 104812 HomoloGene: 27232 GeneCards: OR2A4 Gene
Gene ontology Molecular function • molecular_function • transmembrane signaling receptor activity • G-protein coupled receptor activity • olfactory receptor activity Cellular component • plasma membrane • integral component of membrane • cleavage furrow • recycling endosome • Flemming body • mitotic spindle pole • mitotic spindle midzone Biological process • G-protein coupled receptor signaling pathway • positive regulation of cytokinesis • regulation of actin cytoskeleton organization • detection of chemical stimulus involved in sensory perception • detection of chemical stimulus involved in sensory perception of smell Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79541	18310
Ensembl	ENSG00000180658	ENSMUSG00000043605
UniProt	O95047	P34984
RefSeq (mRNA)	NM_030908	NM_146652
RefSeq (protein)	NP_112170	NP_666863
Location (UCSC)	Chr 6: 131.7 – 131.7 Mb	Chr 6: 43.17 – 43.18 Mb
PubMed search

Olfactory receptor 2A4 is a protein that in humans is encoded by the OR2A4 gene.^[1]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.^[1]

See also

• Olfactory receptor

References

1. "Entrez Gene: OR2A4 olfactory receptor, family 2, subfamily A, member 4".

Further reading

• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• OR2A4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.