OR7A5

Olfactory receptor, family 7, subfamily A, member 5
Identifiers
Symbols	OR7A5 ; HTPCR2
External IDs	HomoloGene: 133620 GeneCards: OR7A5 Gene
Gene ontology Molecular function • G-protein coupled receptor activity • olfactory receptor activity Cellular component • plasma membrane • integral component of membrane Biological process • G-protein coupled receptor signaling pathway • sensory perception of smell • detection of chemical stimulus involved in sensory perception of smell Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	26659	18357
Ensembl	ENSG00000188269	ENSMUSG00000060205
UniProt	Q15622	Q9JHB2
RefSeq (mRNA)	NM_017506	NM_147041
RefSeq (protein)	NP_059976	NP_667252
Location (UCSC)	Chr 19: 14.79 – 14.84 Mb	Chr 10: 79.03 – 79.04 Mb
PubMed search

Olfactory receptor 7A5 is a protein that in humans is encoded by the OR7A5 gene.^[1]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.^[1]

See also

• Olfactory receptor

References

1. "Entrez Gene: OR7A5 olfactory receptor, family 7, subfamily A, member 5".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature 428 (6982): 529–535. doi:10.1038/nature02399. PMID 15057824.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–2589. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
• Vanderhaeghen P, Schurmans S, Vassart G, Parmentier M (1997). "Molecular cloning and chromosomal mapping of olfactory receptor genes expressed in the male germ line: evidence for their wide distribution in the human genome". Biochem. Biophys. Res. Commun. 237 (2): 283–287. doi:10.1006/bbrc.1997.7043. PMID 9268701.
• Vanderhaeghen P, Schurmans S, Vassart G, Parmentier M (1997). "Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species". Genomics 39 (3): 239–246. doi:10.1006/geno.1996.4490. PMID 9119360.
• Parmentier M, Libert F, Schurmans S, et al. (1992). "Expression of members of the putative olfactory receptor gene family in mammalian germ cells". Nature 355 (6359): 453–455. doi:10.1038/355453a0. PMID 1370859.

External links

• OR7A5 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.