Benorilate

Benorilate

Systematic (IUPAC) name
4-(acetylamino)phenyl 2-(acetyloxy)benzoate
Clinical data
Routes of administration	Oral
Identifiers
CAS Number	5003-48-5
ATC code	N02BA10 (WHO)
PubChem	CID 21102
ChemSpider	19846
UNII	W1QX9DV96G
ChEMBL	CHEMBL162036
Chemical data
Formula	C17H15NO5
Molar mass	313.305 g/mol
SMILES O=C(C)Oc2ccccc2C(=O)Oc1ccc(NC(C)=O)cc1
InChI InChI=1S/C17H15NO5/c1-11(19)18-13-7-9-14(10-8-13)23-17(21)15-5-3-4-6-16(15)22-12(2)20/h3-10H,1-2H3,(H,18,19) Key:FEJKLNWAOXSSNR-UHFFFAOYSA-N
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Benorilate (INN), or benorylate, is an ester-linked codrug of aspirin with paracetamol. It is used as an anti-inflammatory and antipyretic medication. In the treatment of childhood fever, it has been shown to be inferior to paracetamol and aspirin taken separately. In addition, because it is converted to aspirin, benorylate is not recommended in children due to concerns about Reye syndrome.^[1]

References

1. Simila S, Keinanen S, Kouvalainen K.Oral antipyretic therapy: evaluation of benorylate, an ester of acetylsalicylic acid and paracetamol. Eur J Pediatr. 1975 Dec 9;121(1):15-20. PMID 2478