Suprofen

Suprofen

Systematic (IUPAC) name
(RS)-2-[4-(2-thienylcarbonyl)phenyl]propanoic acid
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy category	US: C (Risk not ruled out)
Routes of administration	Oral, eye drops
Legal status
Legal status	Discontinued
Pharmacokinetic data
Protein binding	20%
Identifiers
CAS Number	40828-46-4
ATC code	M01AE07 (WHO)
PubChem	CID 5359
IUPHAR/BPS	7298
DrugBank	DB00870
ChemSpider	5166
UNII	988GU2F9PE
KEGG	D00452
ChEBI	CHEBI:9362
ChEMBL	CHEMBL956
Chemical data
Formula	C14H12O3S
Molar mass	260.309 g/mol
SMILES O=C(c1ccc(cc1)C(C(=O)O)C)c2sccc2
InChI InChI=1S/C14H12O3S/c1-9(14(16)17)10-4-6-11(7-5-10)13(15)12-3-2-8-18-12/h2-9H,1H3,(H,16,17) Key:MDKGKXOCJGEUJW-UHFFFAOYSA-N
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Suprofen is a non-steroidal anti-inflammatory drug (NSAID) developed by Janssen Pharmaceutica^[1] that was marketed as 1% eye drops under the trade name Profenal.

Uses

Suprofen was originally used as tablet, but oral uses have been discontinued due to renal effects.^[2] It was subsequently used exclusively as a topical ophthalmic solution, typically to prevent miosis during and after ophthalmic surgery.^[3] This application has been discontinued as well, at least in the US.^[4]

References

1. Janssen, Paul A.; Van Daele, Georges H. P.; Boey, Jozef M. "Antiphlogistic aroyl-substituted phenylacetic acid derivatives" (1974) DE 2353357 
2. Nies A S (1988). "Renal effects of nonsteroidal anti-inflammatory drugs". Agents and actions 24: 95–106. doi:10.1007/978-3-0348-9160-8_9. PMID 3142236.
3. Guidance for FDA Staff and Industry Compliance Policy Guides Manual, Sec. 460.200
4. Drugs.com: suprofen ophthalmic