Src family kinase

Src family kinase is a family of non-receptor tyrosine kinases that includes nine members: Src, Yes, Fyn, and Fgr, forming the SrcA subfamily, Lck, Hck, Blk, and Lyn in the SrcB subfamily, and Frk in its own subfamily. Frk has homologs in invertebrates such as flies and worms, and Src homologs exist in organisms as diverse as unicellular choanoflagellates, but the SrcA and SrcB subfamilies are specific to vertebrates.

Src family kinases interact with many cellular cytosolic, nuclear and membrane proteins, modifying these proteins by phosphorylation of tyrosine residues. A number of substrates have been discovered for these enzymes.^[1]

References

1. Amanchy R, Zhong J, Hong R, Kim JH, Gucek M, Molina H, Pandey A. Identification of c-Src tyrosine kinase substrates in PDGF receptor signaling pathway. Molecular Oncology doi:10.1016/j.molonc.2009.07.001 Amanchy R, Iwahori A, Molina H, Kalume DE, Gronborg M, Joore J, Cope L, Pandey A. Identification of c-Src tyrosine kinase substrates using mass spectrometry and peptide microarrays Journal of Proteome Research. 2008 Sep;7(9):3900-10. Luo W, Slebos RJ, Hill S, Li M, Brábek J, Amanchy R, Chaerkady R, Pandey A, Ham AL and Hanks SK. Global impact of oncogenic Src on a phosphotyrosine proteome Journal of Proteome Research. 2008 Aug;7(8):3447-60.

1. Amanchy R, Zhong J, Hong R, Kim JH, Gucek M, Molina H, Pandey A. Identification of c-Src tyrosine kinase substrates in PDGF receptor signaling pathway. Mol Oncol. 2009 Dec;3(5-6):439-50

2. Amanchy R, Iwahori A, Molina H, Kalume DE, Gronborg M, Joore J, Cope L, Pandey A. Identification of c-Src tyrosine kinase substrates using mass spectrometry and peptide microarrays Journal of Proteome Research. 2008 Sep;7(9):3900-10.

3. Luo W, Slebos RJ, Hill S, Li M, Brábek J, Amanchy R, Chaerkady R, Pandey A, Ham AL and Hanks SK. Global impact of oncogenic Src on a phosphotyrosine proteome Journal of Proteome Research. 2008 Aug;7(8):3447-60.