Endonuclease/Exonuclease/phosphatase family

Endonuclease/Exonuclease/phosphatase family is a structural domain found in the large family of proteins including magnesium dependent endonucleases and many phosphatases involved in intracellular signaling.^[2]

Examples

AP endonuclease proteins EC 4.2.99.18,
DNase I proteins EC 3.1.21.1,
Synaptojanin, an inositol-1,4,5-trisphosphate phosphatase EC 3.1.3.56
Sphingomyelinase EC 3.1.4.12 and Nocturnin O35710.

Subfamilies

Inositol polyphosphate related phosphatase IPR000300

Human proteins containing this domain

2'-PDE; 2-PDE; ANGEL1; ANGEL2; APEX1; APEX2; CCRN4L; CNOT6; CNOT6L; DNASE1; DNASE1L1; DNASE1L2; DNASE1L3; INPP5A; INPP5B; INPP5D; INPP5E; INPPL1; KIAA1706; OCRL; PIB5PA; SKIP; SMPD2; SMPD3; SYNJ1; SYNJ2; TTRAP;

Notes

↑ Mol CD, Kuo CF, Thayer MM, Cunningham RP, Tainer JA (March 1995). "Structure and function of the multifunctional DNA-repair enzyme exonuclease III". Nature 374 (6520): 381–6. doi:10.1038/374381a0. PMID 7885481.
↑ Dlaki M (2000). "Functionally unrelated signalling proteins contain a fold similar to Mg2+-dependent endonucleases". Trends Biochem. Sci. 25 (6): 272–273. doi:10.1016/S0968-0004(00)01582-6. PMID 10838565.

References

Dlakić M (June 2000). "Functionally unrelated signalling proteins contain a fold similar to Mg²⁺-dependent endonucleases". Trends Biochem. Sci. 25 (6): 272–3. doi:10.1016/S0968-0004(00)01582-6. PMID 10838565.
Mol CD, Kuo CF, Thayer MM, Cunningham RP, Tainer JA (March 1995). "Structure and function of the multifunctional DNA-repair enzyme exonuclease III". Nature 374 (6520): 381–6. doi:10.1038/374381a0. PMID 7885481.
Lahm A, Suck D (December 1991). "DNase I-induced DNA conformation. 2 A structure of a DNase I-octamer complex". J. Mol. Biol. 222 (3): 645–67. doi:10.1016/0022-2836(91)90502-W. PMID 1748997.

Hydrolase: esterases (EC 3.1)

3.1.1: Carboxylic
ester hydrolases

Lipase

Phospholipase
- A1
- A2
- B

3.1.2: Thioesterase

3.1.3: Phosphatase

3.1.4: Phosphodiesterase

3.1.6: Sulfatase

Nuclease (includes
deoxyribonuclease and
ribonuclease)

3.1.11-16: Exonuclease

Exodeoxyribonuclease	RecBCD

Exoribonuclease	Oligonucleotidase

3.1.21-31: Endonuclease

Endodeoxyribonuclease	Deoxyribonuclease I Deoxyribonuclease II Deoxyribonuclease IV Restriction enzyme UvrABC endonuclease

Endoribonuclease	RNase III RNase H 1 2A 2B 2C RNase P RNase A 1 2 3 4/5 RNase T1 RNA-induced silencing complex

either deoxy- or ribo-	Aspergillus nuclease S1 Micrococcal nuclease

Proteins: enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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