UK-414,495
 | |
| Systematic (IUPAC) name | |
|---|---|
|
(R)-2-({1-[(5-ethyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl}methyl)valeric acid | |
| Identifiers | |
| CAS Number | 337962-93-3 |
| PubChem | CID 9949799 |
| Chemical data | |
| Formula | C16H25N3O3S |
| Molar mass | 339.452 g/mol |
| |
| (verify) | |
UK-414,495 is a drug developed by Pfizer for the treatment of female sexual arousal disorder.[1] UK-414,495 acts as a potent, selective inhibitor of the enzyme neutral endopeptidase, which normally serves to break down the neuropeptide VIP. The consequent increase in VIP activity alters blood flow to the genital region leading to increased lubrication and muscle relaxation.[2][3][4]
See also
- ABT-670
- ABT-724
- Bremelanotide
- Cabergoline
- Flibanserin
- Intrinsa
- Melanotan II
- Pramipexole
- PF-219,061
- S-17092
- Tibolone
References
- ↑ 'Female Viagra' will help women increase their sexual arousal. Daily Mail Online 14 April 2010
- ↑ Armer R, Warne P, Witherington J (2006). "Recent disclosures of clinical drug candidates". Drug News & Perspectives 19 (1): 65–72. ISSN 0214-0934. PMID 16550257.
- ↑ Angulo, J. (2010). "Neutral endopeptidase inhibition: could it have a role in the treatment of female sexual arousal disorder?". British Journal of Pharmacology 160 (1): 48–50. doi:10.1111/j.1476-5381.2010.00693.x. PMC: 2860205. PMID 20412067.
- ↑ Wayman, C.; Baxter, D.; Turner, L.; Van Der Graaf, P.; Naylor, A. (2010). "UK-414,495, a selective inhibitor of neutral endopeptidase, potentiates pelvic nerve-stimulated increases in female genital blood flow in the anaesthetized rabbit". British Journal of Pharmacology 160 (1): 51–59. doi:10.1111/j.1476-5381.2010.00691.x. PMC: 2860206. PMID 20412068.
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