Monocarboxylate transporter 10

Solute carrier family 16 (aromatic amino acid transporter), member 10
Identifiers
Symbols	SLC16A10 ; MCT10; PRO0813; TAT1
External IDs	OMIM: 607550 HomoloGene: 75089 IUPHAR: 993 GeneCards: SLC16A10 Gene
Gene ontology Molecular function • transporter activity • aromatic amino acid transmembrane transporter activity • thyroid hormone transmembrane transporter activity Cellular component • plasma membrane • integral component of plasma membrane • integral component of membrane • basolateral plasma membrane Biological process • ion transport • amino acid transport • aromatic amino acid transport • ion transmembrane transport • transmembrane transport • thyroid hormone transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	117247	72472
Ensembl	ENSG00000112394	ENSMUSG00000019838
UniProt	Q8TF71	Q3U9N9
RefSeq (mRNA)	NM_018593	NM_001114332
RefSeq (protein)	NP_061063	NP_001107804
Location (UCSC)	Chr 6: 111.09 – 111.23 Mb	Chr 10: 40.03 – 40.14 Mb
PubMed search

Monocarboxylate transporter 10 (MCT 10), also known as aromatic amino acid transporter 1 and T-type amino acid transporter 1 (TAT1) and solute carrier family 16 member 10 (SLC16A10), is a protein that in humans is encoded by the SLC16A10 gene.^[1][2][3] SLC16A10 is a member of the solute carrier family.

Function

SLC16A10 mediates Na⁺-independent transport of tryptophan, tyrosine, phenylalanine, and L-DOPA.^[3]

See also

• Blue diaper syndrome

References

1. "Entrez Gene: solute carrier family 16".
2. Kim DK, Kanai Y, Chairoungdua A, Matsuo H, Cha SH, Endou H (May 2001). "Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters". J. Biol. Chem. 276 (20): 17221–8. doi:10.1074/jbc.M009462200. PMID 11278508.
3. Kim DK, Kanai Y, Matsuo H, Kim JY, Chairoungdua A, Kobayashi Y, Enomoto A, Cha SH, Goya T, Endou H (January 2002). "The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location". Genomics 79 (1): 95–103. doi:10.1006/geno.2001.6678. PMID 11827462.

Further reading

• Toure A, Morin L, Pineau C, et al. (2001). "Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling.". J. Biol. Chem. 276 (23): 20309–15. doi:10.1074/jbc.M011740200. PMID 11278976.
• Friesema EC, Jansen J, Jachtenberg JW, et al. (2008). "Effective cellular uptake and efflux of thyroid hormone by human monocarboxylate transporter 10.". Mol. Endocrinol. 22 (6): 1357–69. doi:10.1210/me.2007-0112. PMID 18337592.
• Loubière LS, Vasilopoulou E, Bulmer JN; et al. (2010). "Expression of thyroid hormone transporters in the human placenta and changes associated with intrauterine growth restriction.". Placenta 31 (4): 295–304. doi:10.1016/j.placenta.2010.01.013. PMID 20167367.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bröer S (2008). "Amino acid transport across mammalian intestinal and renal epithelia.". Physiol. Rev. 88 (1): 249–86. doi:10.1152/physrev.00018.2006. PMID 18195088.
• Park SY, Kim JK, Kim IJ, et al. (2005). "Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule.". Arch. Pharm. Res. 28 (4): 421–32. doi:10.1007/BF02977671. PMID 15918515.
• Halestrap AP, Meredith D (2004). "The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond.". Pflugers Arch. 447 (5): 619–28. doi:10.1007/s00424-003-1067-2. PMID 12739169.