Monocarboxylate transporter 5

Solute carrier family 16, member 4
Identifiers
Symbols	SLC16A4 ; MCT4; MCT5
External IDs	OMIM: 603878 MGI: 2385183 HomoloGene: 74529 GeneCards: SLC16A4 Gene
Gene ontology Molecular function • monocarboxylic acid transmembrane transporter activity • symporter activity Cellular component • integral component of plasma membrane • membrane Biological process • monocarboxylic acid transport • ion transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9122	229699
Ensembl	ENSG00000168679	ENSMUSG00000027896
UniProt	O15374	Q8R0M8
RefSeq (mRNA)	NM_001201546	NM_146136
RefSeq (protein)	NP_001188475	NP_666248
Location (UCSC)	Chr 1: 110.36 – 110.39 Mb	Chr 3: 107.29 – 107.31 Mb
PubMed search

Monocarboxylate transporter 5 is a protein that in humans is encoded by the SLC16A4 gene.^[1][2]

See also

• Solute carrier family

References

1. Price NT, Jackson VN, Halestrap AP (Feb 1998). "Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past". Biochem J 329 (2): 321–8. PMC 1219047. PMID 9425115.
2. "Entrez Gene: SLC16A4 solute carrier family 16, member 4 (monocarboxylic acid transporter 5)".

Further reading

• Halestrap AP, Price NT (1999). "The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation.". Biochem. J. 343 (2): 281–99. doi:10.1042/0264-6021:3430281. PMC 1220552. PMID 10510291.
• Halestrap AP, Meredith D (2004). "The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond.". Pflugers Arch. 447 (5): 619–28. doi:10.1007/s00424-003-1067-2. PMID 12739169.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Pilegaard H, Terzis G, Halestrap A, Juel C (1999). "Distribution of the lactate/H+ transporter isoforms MCT1 and MCT4 in human skeletal muscle.". Am. J. Physiol. 276 (5 Pt 1): E843–8. PMID 10329977.
• Manning Fox JE, Meredith D, Halestrap AP (2001). "Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle.". J. Physiol. (Lond.) 529 (2): 285–93. doi:10.1111/j.1469-7793.2000.00285.x. PMC 2270204. PMID 11101640.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Philp NJ, Wang D, Yoon H, Hjelmeland LM (2003). "Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells.". Invest. Ophthalmol. Vis. Sci. 44 (4): 1716–21. doi:10.1167/iovs.02-0287. PMID 12657613.
• Juel C, Holten MK, Dela F (2004). "Effects of strength training on muscle lactate release and MCT1 and MCT4 content in healthy and type 2 diabetic humans.". J. Physiol. (Lond.) 556 (Pt 1): 297–304. doi:10.1113/jphysiol.2003.058222. PMC 1664883. PMID 14724187.
• Settle P, Mynett K, Speake P, et al. (2004). "Polarized lactate transporter activity and expression in the syncytiotrophoblast of the term human placenta.". Placenta 25 (6): 496–504. doi:10.1016/j.placenta.2003.11.009. PMID 15135232.
• Wilson MC, Meredith D, Fox JE, et al. (2005). "Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70).". J. Biol. Chem. 280 (29): 27213–21. doi:10.1074/jbc.M411950200. PMID 15917240.
• Merezhinskaya N, Ogunwuyi SA, Fishbein WN (2006). "Expression of monocarboxylate transporter 4 in human platelets, leukocytes, and tissues assessed by antibodies raised against terminal versus pre-terminal peptides.". Mol. Genet. Metab. 87 (2): 152–61. doi:10.1016/j.ymgme.2005.09.029. PMID 16403666.
• Bickham DC, Bentley DJ, Le Rossignol PF, Cameron-Smith D (2006). "The effects of short-term sprint training on MCT expression in moderately endurance-trained runners.". Eur. J. Appl. Physiol. 96 (6): 636–43. doi:10.1007/s00421-005-0100-x. PMID 16408234.
• Ullah MS, Davies AJ, Halestrap AP (2006). "The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism.". J. Biol. Chem. 281 (14): 9030–7. doi:10.1074/jbc.M511397200. PMID 16452478.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Bishop D, Edge J, Thomas C, Mercier J (2007). "High-intensity exercise acutely decreases the membrane content of MCT1 and MCT4 and buffer capacity in human skeletal muscle.". J. Appl. Physiol. 102 (2): 616–21. doi:10.1152/japplphysiol.00590.2006. PMID 17082373.