Solute carrier family 35 (CMP-sialic acid transporter), member A1

Solute carrier family 35 (CMP-sialic acid transporter), member A1
Identifiers
Symbols	SLC35A1 ; CDG2F; CMPST; CST; hCST
External IDs	OMIM: 605634 MGI: 1345622 HomoloGene: 38181 GeneCards: SLC35A1 Gene
Gene ontology Molecular function • sugar:proton symporter activity • CMP-N-acetylneuraminate transmembrane transporter activity Cellular component • Golgi membrane • Golgi apparatus • integral component of plasma membrane Biological process • carbohydrate metabolic process • cellular protein modification process • dolichol-linked oligosaccharide biosynthetic process • carbohydrate transport • CMP-N-acetylneuraminate transport • proton transport • protein N-linked glycosylation via asparagine • post-translational protein modification • cellular protein metabolic process • transmembrane transport • nucleotide transmembrane transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10559	24060
Ensembl	ENSG00000164414	ENSMUSG00000028293
UniProt	P78382	Q61420
RefSeq (mRNA)	NM_001168398	NM_011895
RefSeq (protein)	NP_001161870	NP_036025
Location (UCSC)	Chr 6: 87.47 – 87.51 Mb	Chr 4: 34.66 – 34.69 Mb
PubMed search

CMP-sialic acid transporter is a protein that in humans is encoded by the SLC35A1 gene.^[1][2][3]

See also

• Solute carrier family

References

1. Ishida N, Miura N, Yoshioka S, Kawakita M (Apr 1997). "Molecular cloning and characterization of a novel isoform of the human UDP-galactose transporter, and of related complementary DNAs belonging to the nucleotide-sugar transporter gene family". J Biochem 120 (6): 1074–8. doi:10.1093/oxfordjournals.jbchem.a021523. PMID 9010752.
2. Ishida N, Ito M, Yoshioka S, Sun-Wada GH, Kawakita M (Sep 1998). "Functional expression of human golgi CMP-sialic acid transporter in the Golgi complex of a transporter-deficient Chinese hamster ovary cell mutant". J Biochem 124 (1): 171–8. doi:10.1093/oxfordjournals.jbchem.a022076. PMID 9644260.
3. "Entrez Gene: SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1".

Further reading

• Wahlberg JE (1976). "Sensitization and testing of guinea pigs with nickel sulfate.". Dermatologica 152 (6): 321–30. doi:10.1159/000251278. PMID 964426.
• Harvey BE, Thomas P (1993). "Inhibition of CMP-sialic acid transport in human liver and colorectal cancer cell lines by a sialic acid nucleoside conjugate (KI-8110).". Biochem. Biophys. Res. Commun. 190 (2): 571–5. doi:10.1006/bbrc.1993.1086. PMID 8427599.
• Lennon G, Auffray C, Polymeropoulos M, Soares MB (1996). "The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression.". Genomics 33 (1): 151–2. doi:10.1006/geno.1996.0177. PMID 8617505.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Aoki K, Ishida N, Kawakita M (2003). "Substrate recognition by nucleotide sugar transporters: further characterization of substrate recognition regions by analyses of UDP-galactose/CMP-sialic acid transporter chimeras and biochemical analysis of the substrate specificity of parental and chimeric transporters.". J. Biol. Chem. 278 (25): 22887–93. doi:10.1074/jbc.M302620200. PMID 12682060.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Martinez-Duncker I, Dupré T, Piller V, et al. (2005). "Genetic complementation reveals a novel human congenital disorder of glycosylation of type II, due to inactivation of the Golgi CMP-sialic acid transporter.". Blood 105 (7): 2671–6. doi:10.1182/blood-2004-09-3509. PMID 15576474.
• Misaki R, Fujiyama K, Seki T (2006). "Expression of human CMP-N-acetylneuraminic acid synthetase and CMP-sialic acid transporter in tobacco suspension-cultured cell.". Biochem. Biophys. Res. Commun. 339 (4): 1184–9. doi:10.1016/j.bbrc.2005.11.130. PMID 16343442.
• Zhao W, Chen TL, Vertel BM, Colley KJ (2006). "The CMP-sialic acid transporter is localized in the medial-trans Golgi and possesses two specific endoplasmic reticulum export motifs in its carboxyl-terminal cytoplasmic tail.". J. Biol. Chem. 281 (41): 31106–18. doi:10.1074/jbc.M605564200. PMID 16923816.

External links

• GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview