Platelet-activating factor receptor

Platelet-activating factor receptor
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2B0X​
Identifiers
Symbols	PTAFR ; PAFR
External IDs	OMIM: 173393 MGI: 106066 HomoloGene: 20260 IUPHAR: 334 ChEMBL: 250 GeneCards: PTAFR Gene
Gene ontology Molecular function • lipopolysaccharide binding • lipopolysaccharide receptor activity • G-protein coupled receptor activity • platelet activating factor receptor activity • phospholipid binding • G-protein coupled purinergic nucleotide receptor activity Cellular component • nucleoplasm • plasma membrane • integral component of plasma membrane • membrane • integral component of membrane • intracellular membrane-bounded organelle Biological process • cytokine production • chemotaxis • inflammatory response • immune response • G-protein coupled receptor signaling pathway • cytokine-mediated signaling pathway • lipopolysaccharide-mediated signaling pathway • inositol trisphosphate biosynthetic process • G-protein coupled purinergic nucleotide receptor signaling pathway • phosphatidylinositol-mediated signaling • interferon-gamma-mediated signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5724	19204
Ensembl	ENSG00000169403	ENSMUSG00000056529
UniProt	P25105	Q62035
RefSeq (mRNA)	NM_000952	NM_001081211
RefSeq (protein)	NP_000943	NP_001074680
Location (UCSC)	Chr 1: 28.15 – 28.19 Mb	Chr 4: 132.56 – 132.58 Mb
PubMed search

The platelet-activating factor receptor is a G-protein coupled receptor which binds platelet-activating factor.^[1][2]

The PAF receptor shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.[supplied by OMIM]^[3] Its pathogenetic role in chronic kidney failure has also been reported recently. ^[4]

Ligands

Agonists

• Platelet activating factor

Antagonists

• Israpafant (Y-24180)
• WEB 2086

References

1. Seyfried CE, Schweickart VL, Godiska R, Gray PW (1992). "The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1". Genomics 13 (3): 832–4. doi:10.1016/0888-7543(92)90162-L. PMID 1322356.
2. Ishii S, Nagase T, Shimizu T (2002). "Platelet-activating factor receptor". Prostaglandins Other Lipid Mediat. 68-69: 599–609. doi:10.1016/S0090-6980(02)00058-8. PMID 12432946.
3. "Entrez Gene: PTAFR platelet-activating factor receptor".
4. Correa-Costa M (Apr 2014). "Activation of platelet-activating factor receptor exacerbates renal inflammation and promotes fibrosis.". Lab Invest. 94 (4): 455–466. doi:10.1038/labinvest.2013.155. PMID 24492283.

Further reading

• Shukla SD (1992). "Platelet-activating factor receptor and signal transduction mechanisms.". FASEB J. 6 (6): 2296–301. PMID 1312046.
• Sugimoto T, Tsuchimochi H, McGregor CG, et al. (1993). "Molecular cloning and characterization of the platelet-activating factor receptor gene expressed in the human heart.". Biochem. Biophys. Res. Commun. 189 (2): 617–24. doi:10.1016/0006-291X(92)92245-S. PMID 1281995.
• Seyfried CE, Schweickart VL, Godiska R, Gray PW (1992). "The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1.". Genomics 13 (3): 832–4. doi:10.1016/0888-7543(92)90162-L. PMID 1322356.
• Kunz D, Gerard NP, Gerard C (1992). "The human leukocyte platelet-activating factor receptor. cDNA cloning, cell surface expression, and construction of a novel epitope-bearing analog.". J. Biol. Chem. 267 (13): 9101–6. PMID 1374385.
• Ye RD, Prossnitz ER, Zou AH, Cochrane CG (1991). "Characterization of a human cDNA that encodes a functional receptor for platelet activating factor.". Biochem. Biophys. Res. Commun. 180 (1): 105–11. doi:10.1016/S0006-291X(05)81261-6. PMID 1656963.
• Nakamura M, Honda Z, Izumi T, et al. (1991). "Molecular cloning and expression of platelet-activating factor receptor from human leukocytes.". J. Biol. Chem. 266 (30): 20400–5. PMID 1657923.
• Haslam RJ, Williams KA, Davidson MM (1986). "Receptor-effector coupling in platelets: roles of guanine nucleotides.". Adv. Exp. Med. Biol. 192: 265–80. doi:10.1007/978-1-4615-9442-0_19. PMID 3010668.
• Valone FH (1984). "Isolation of a platelet membrane protein which binds the platelet-activating factor 1-0-hexadecyl-2-acetyl-SN-glycero-3-phosphorylcholine.". Immunology 52 (1): 169–74. PMC 1454573. PMID 6325330.
• Cundell DR, Gerard NP, Gerard C, et al. (1995). "Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factor.". Nature 377 (6548): 435–8. doi:10.1038/377435a0. PMID 7566121.
• Izumi T, Kishimoto S, Takano T, et al. (1995). "Expression of human platelet-activating factor receptor gene in EoL-1 cells following butyrate-induced differentiation.". Biochem. J. 305. ( Pt 3): 829–35. PMC 1136334. PMID 7848283.
• Bito H, Honda Z, Nakamura M, Shimizu T (1994). "Cloning, expression and tissue distribution of rat platelet-activating-factor-receptor cDNA.". Eur. J. Biochem. 221 (1): 211–8. doi:10.1111/j.1432-1033.1994.tb18731.x. PMID 8168510.
• Chase PB, Halonen M, Regan JW (1993). "Cloning of a human platelet-activating factor receptor gene: evidence for an intron in the 5'-untranslated region.". Am. J. Respir. Cell Mol. Biol. 8 (3): 240–4. doi:10.1165/ajrcmb/8.3.240. PMID 8383507.
• Mutoh H, Bito H, Minami M, et al. (1993). "Two different promoters direct expression of two distinct forms of mRNAs of human platelet-activating factor receptor.". FEBS Lett. 322 (2): 129–34. doi:10.1016/0014-5793(93)81552-B. PMID 8387031.
• Nakamura M, Honda Z, Matsumoto T, et al. (1993). "Isolation and properties of platelet-activating factor receptor cDNAs.". Journal of lipid mediators 6 (1-3): 163–8. PMID 8395240.
• Kishimoto S, Shimadzu W, Izumi T, et al. (1996). "Regulation by IL-5 of expression of functional platelet-activating factor receptors on human eosinophils.". J. Immunol. 157 (9): 4126–32. PMID 8892648.
• Chase PB, Yang JM, Thompson FH, et al. (1997). "Regional mapping of the human platelet-activating factor receptor gene (PTAFR) to 1p35→p34.3 by fluorescence in situ hybridization.". Cytogenet. Cell Genet. 72 (2-3): 205–7. doi:10.1159/000134190. PMID 8978777.
• Le Gouill C, Parent JL, Rola-Pleszczynski M, Stanková J (1997). "Role of the Cys90, Cys95 and Cys173 residues in the structure and function of the human platelet-activating factor receptor.". FEBS Lett. 402 (2-3): 203–8. doi:10.1016/S0014-5793(96)01531-1. PMID 9037196.
• Ahmed A, Dearn S, Shams M, et al. (1998). "Localization, quantification, and activation of platelet-activating factor receptor in human endometrium during the menstrual cycle: PAF stimulates NO, VEGF, and FAKpp125.". FASEB J. 12 (10): 831–43. PMID 9657523.
• Cargill M, Altshuler D, Ireland J, et al. (1999). "Characterization of single-nucleotide polymorphisms in coding regions of human genes.". Nat. Genet. 22 (3): 231–8. doi:10.1038/10290. PMID 10391209.

External links

• "Platelet-Activating Factor Receptor". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
• platelet activating factor receptor at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.