CAMK1

Calcium/calmodulin-dependent protein kinase I
PDB rendering based on 1a06.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4FG7​, 4FG8​, 4FG9​, 4FGB​
Identifiers
Symbols	CAMK1 ; CAMKI
External IDs	OMIM: 604998 MGI: 1098535 HomoloGene: 117458 ChEMBL: 2493 GeneCards: CAMK1 Gene
EC number	2.7.11.17
Gene ontology Molecular function • calmodulin-dependent protein kinase activity • protein binding • calmodulin binding • ATP binding Cellular component • nucleus • cytoplasm Biological process • protein phosphorylation • nucleocytoplasmic transport • cell cycle • signal transduction • positive regulation of neuron projection development • negative regulation of protein binding • regulation of protein localization • positive regulation of peptidyl-serine phosphorylation • regulation of protein binding • positive regulation of transcription from RNA polymerase II promoter • positive regulation of protein export from nucleus • regulation of muscle cell differentiation • positive regulation of muscle cell differentiation • positive regulation of synapse structural plasticity • positive regulation of syncytium formation by plasma membrane fusion • positive regulation of dendritic spine development • positive regulation of protein serine/threonine kinase activity • positive regulation of protein acetylation • regulation of histone H3-K9 acetylation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8536	52163
Ensembl	ENSG00000134072	ENSMUSG00000030272
UniProt	Q14012	Q91YS8
RefSeq (mRNA)	NM_003656	NM_133926
RefSeq (protein)	NP_003647	NP_598687
Location (UCSC)	Chr 3: 9.76 – 9.77 Mb	Chr 6: 113.33 – 113.34 Mb
PubMed search

Calcium/calmodulin-dependent protein kinase type 1 is an enzyme that in humans is encoded by the CAMK1 gene.^[1][2]

Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase.^[2]

References

1. Haribabu B, Hook SS, Selbert MA, Goldstein EG, Tomhave ED, Edelman AM, Snyderman R, Means AR (Sep 1995). "Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase". EMBO J 14 (15): 3679–86. PMC 394442. PMID 7641687.
2. "Entrez Gene: CAMK1 calcium/calmodulin-dependent protein kinase I".

Further reading

• Bredt DS, Ferris CD, Snyder SH (1992). "Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites". J. Biol. Chem. 267 (16): 10976–81. PMID 1375933.
• Yokokura H, Picciotto MR, Nairn AC, Hidaka H (1995). "The regulatory region of calcium/calmodulin-dependent protein kinase I contains closely associated autoinhibitory and calmodulin-binding domains". J. Biol. Chem. 270 (40): 23851–9. doi:10.1074/jbc.270.40.23851. PMID 7559563.
• Liu F, Thompson MA, Wagner S; et al. (1993). "Activating transcription factor-1 can mediate Ca(2+)- and cAMP-inducible transcriptional activation". J. Biol. Chem. 268 (9): 6714–20. PMID 8384217.
• Chin D, Winkler KE, Means AR (1998). "Characterization of substrate phosphorylation and use of calmodulin mutants to address implications from the enzyme crystal structure of calmodulin-dependent protein kinase I". J. Biol. Chem. 272 (50): 31235–40. doi:10.1074/jbc.272.50.31235. PMID 9395448.
• Hsu LS, Tsou AP, Chi CW; et al. (1998). "Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase". J. Biomed. Sci. 5 (2): 141–9. doi:10.1007/bf02258368. PMID 9662074.
• Matsushita M, Nairn AC (1998). "Characterization of the mechanism of regulation of Ca2+/ calmodulin-dependent protein kinase I by calmodulin and by Ca2+/calmodulin-dependent protein kinase kinase". J. Biol. Chem. 273 (34): 21473–81. doi:10.1074/jbc.273.34.21473. PMID 9705275.
• Anderson KA, Means RL, Huang QH; et al. (1998). "Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta". J. Biol. Chem. 273 (48): 31880–9. doi:10.1074/jbc.273.48.31880. PMID 9822657.
• Matsushita M, Nairn AC (1999). "Inhibition of the Ca2+/calmodulin-dependent protein kinase I cascade by cAMP-dependent protein kinase". J. Biol. Chem. 274 (15): 10086–93. doi:10.1074/jbc.274.15.10086. PMID 10187789.
• Hayashi Y, Nishio M, Naito Y; et al. (1999). "Regulation of neuronal nitric-oxide synthase by calmodulin kinases". J. Biol. Chem. 274 (29): 20597–602. doi:10.1074/jbc.274.29.20597. PMID 10400690.
• Hosaka M, Hammer RE, Südhof TC (1999). "A phospho-switch controls the dynamic association of synapsins with synaptic vesicles". Neuron 24 (2): 377–87. doi:10.1016/S0896-6273(00)80851-X. PMID 10571231.
• Komeima K, Hayashi Y, Naito Y, Watanabe Y (2000). "Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells". J. Biol. Chem. 275 (36): 28139–43. doi:10.1074/jbc.M003198200. PMID 10874031.
• McKinsey TA, Zhang CL, Lu J, Olson EN (2000). "Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation". Nature 408 (6808): 106–11. doi:10.1038/35040593. PMID 11081517.
• McKinsey TA, Zhang CL, Olson EN (2001). "Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14400–5. doi:10.1073/pnas.260501497. PMC 18930. PMID 11114197.
• Hsu LS, Chen GD, Lee LS; et al. (2001). "Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity". J. Biol. Chem. 276 (33): 31113–23. doi:10.1074/jbc.M011720200. PMID 11395482.
• Condon JC, Pezzi V, Drummond BM; et al. (2002). "Calmodulin-dependent kinase I regulates adrenal cell expression of aldosterone synthase". Endocrinology 143 (9): 3651–7. doi:10.1210/en.2001-211359. PMID 12193581.
• Sakurada K, Kato H, Nagumo H; et al. (2003). "Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC12 cells stimulated with bradykinin". J. Biol. Chem. 277 (47): 45473–9. doi:10.1074/jbc.M206673200. PMID 12237306.
• Clapperton JA, Martin SR, Smerdon SJ; et al. (2003). "Structure of the complex of calmodulin with the target sequence of calmodulin-dependent protein kinase I: studies of the kinase activation mechanism". Biochemistry 41 (50): 14669–79. doi:10.1021/bi026660t. PMID 12475216.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Izmailova E, Bertley FM, Huang Q; et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042.