CAMK4

Calcium/calmodulin-dependent protein kinase IV
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2W4O​
Identifiers
Symbols	CAMK4 ; CaMK IV; CaMK-GR; IV; caMK
External IDs	OMIM: 114080 MGI: 88258 HomoloGene: 100780 ChEMBL: 2494 GeneCards: CAMK4 Gene
EC number	2.7.11.17
Gene ontology Molecular function • calmodulin-dependent protein kinase activity • calmodulin binding • ATP binding • calcium-dependent protein serine/threonine kinase activity Cellular component • nucleoplasm • nucleolus • cytoplasm • cytosol • extracellular exosome Biological process • adaptive immune response • myeloid dendritic cell cytokine production • protein phosphorylation • nucleocytoplasmic transport • inflammatory response • signal transduction • epidermal growth factor receptor signaling pathway • activation of phospholipase C activity • synaptic transmission • neuron-neuron synaptic transmission • long-term memory • fibroblast growth factor receptor signaling pathway • peptidyl-serine phosphorylation • regulation of T cell differentiation in thymus • intracellular signal transduction • myeloid dendritic cell differentiation • innate immune response • regulation of osteoclast differentiation • positive regulation of transcription, DNA-templated • protein autophosphorylation • positive regulation of protein export from nucleus • neurotrophin TRK receptor signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	814	12326
Ensembl	ENSG00000152495	ENSMUSG00000038128
UniProt	Q16566	Q8BGR3
RefSeq (mRNA)	NM_001744	NM_009793
RefSeq (protein)	NP_001735	NP_033923
Location (UCSC)	Chr 5: 111.22 – 111.49 Mb	Chr 18: 32.94 – 33.2 Mb
PubMed search

Calcium/calmodulin-dependent protein kinase type IV is an enzyme that in humans is encoded by the CAMK4 gene.^[1]

The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca²⁺/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells.^[2]

References

1. Sikela JM, Law ML, Kao FT, Hartz JA, Wei Q, Hahn WE (Mar 1989). "Chromosomal localization of the human gene for brain Ca²⁺/calmodulin-dependent protein kinase type IV". Genomics 4 (1): 21–7. doi:10.1016/0888-7543(89)90309-1. PMID 2536634.
2. "Entrez Gene: CAMK4 calcium/calmodulin-dependent protein kinase IV".

Further reading

• Bredt DS, Ferris CD, Snyder SH (1992). "Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites". J. Biol. Chem. 267 (16): 10976–81. PMID 1375933.
• Jensen KF, Ohmstede CA, Fisher RS, Sahyoun N (1991). "Nuclear and axonal localization of Ca²⁺/calmodulin-dependent protein kinase type Gr in rat cerebellar cortex". Proc. Natl. Acad. Sci. U.S.A. 88 (7): 2850–3. doi:10.1073/pnas.88.7.2850. PMC 51337. PMID 2011593.
• Selbert MA, Anderson KA, Huang QH; et al. (1995). "Phosphorylation and activation of Ca²⁺-calmodulin-dependent protein kinase IV by Ca²⁺-calmodulin-dependent protein kinase Ia kinase. Phosphorylation of threonine 196 is essential for activation". J. Biol. Chem. 270 (29): 17616–21. doi:10.1074/jbc.270.29.17616. PMID 7615569.
• Kitani T, Okuno S, Fujisawa H (1994). "cDNA cloning and expression of human calmodulin-dependent protein kinase IV". J. Biochem. 115 (4): 637–40. PMID 8089075.
• Mosialos G, Hanissian SH, Jawahar S; et al. (1994). "A Ca²⁺/calmodulin-dependent protein kinase, CaM kinase-Gr, expressed after transformation of primary human B lymphocytes by Epstein-Barr virus (EBV) is induced by the EBV oncogene LMP1". J. Virol. 68 (3): 1697–705. PMC 236629. PMID 8107230.
• Bland MM, Monroe RS, Ohmstede CA (1994). "The cDNA sequence and characterization of the Ca²⁺/calmodulin-dependent protein kinase-Gr from human brain and thymus". Gene 142 (2): 191–7. doi:10.1016/0378-1119(94)90260-7. PMID 8194751.
• Tokumitsu H, Soderling TR (1996). "Requirements for calcium and calmodulin in the calmodulin kinase activation cascade". J. Biol. Chem. 271 (10): 5617–22. doi:10.1074/jbc.271.10.5617. PMID 8621423.
• Chatila T, Anderson KA, Ho N, Means AR (1996). "A unique phosphorylation-dependent mechanism for the activation of Ca²⁺/calmodulin-dependent protein kinase type IV/GR". J. Biol. Chem. 271 (35): 21542–8. doi:10.1074/jbc.271.35.21542. PMID 8702940.
• Melander Gradin H, Marklund U, Larsson N; et al. (1997). "Regulation of microtubule dynamics by Ca²⁺/calmodulin-dependent kinase IV/Gr-dependent phosphorylation of oncoprotein 18". Mol. Cell. Biol. 17 (6): 3459–67. PMC 232199. PMID 9154845.
• Matsushita M, Nairn AC (1998). "Characterization of the mechanism of regulation of Ca²⁺/ calmodulin-dependent protein kinase I by calmodulin and by Ca²⁺/calmodulin-dependent protein kinase kinase". J. Biol. Chem. 273 (34): 21473–81. doi:10.1074/jbc.273.34.21473. PMID 9705275.
• Anderson KA, Means RL, Huang QH; et al. (1998). "Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca²⁺/calmodulin-dependent protein kinase kinase beta". J. Biol. Chem. 273 (48): 31880–9. doi:10.1074/jbc.273.48.31880. PMID 9822657.
• Hayashi Y, Nishio M, Naito Y; et al. (1999). "Regulation of neuronal nitric-oxide synthase by calmodulin kinases". J. Biol. Chem. 274 (29): 20597–602. doi:10.1074/jbc.274.29.20597. PMID 10400690.
• Blaeser F, Ho N, Prywes R, Chatila TA (2000). "Ca²⁺-dependent gene expression mediated by MEF2 transcription factors". J. Biol. Chem. 275 (1): 197–209. doi:10.1074/jbc.275.1.197. PMID 10617605.
• Moreno CS, Park S, Nelson K; et al. (2000). "WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A". J. Biol. Chem. 275 (8): 5257–63. doi:10.1074/jbc.275.8.5257. PMC 3505218. PMID 10681496.
• Komeima K, Hayashi Y, Naito Y, Watanabe Y (2000). "Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells". J. Biol. Chem. 275 (36): 28139–43. doi:10.1074/jbc.M003198200. PMID 10874031.
• Wu JY, Ribar TJ, Cummings DE; et al. (2000). "Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Camk4". Nat. Genet. 25 (4): 448–52. doi:10.1038/78153. PMID 10932193.
• Jang MK, Goo YH, Sohn YC; et al. (2001). "Ca²⁺/calmodulin-dependent protein kinase IV stimulates nuclear factor-kappa B transactivation via phosphorylation of the p65 subunit". J. Biol. Chem. 276 (23): 20005–10. doi:10.1074/jbc.M010211200. PMID 11274168.
• Hsu LS, Chen GD, Lee LS; et al. (2001). "Human Ca²⁺/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity". J. Biol. Chem. 276 (33): 31113–23. doi:10.1074/jbc.M011720200. PMID 11395482.
• Zhao X, Ito A, Kane CD; et al. (2001). "The modular nature of histone deacetylase HDAC4 confers phosphorylation-dependent intracellular trafficking". J. Biol. Chem. 276 (37): 35042–8. doi:10.1074/jbc.M105086200. PMID 11470791.
• Ainhoa Bilbaoa, Jan Rodriguez Parkitnab, David Engblomb, Stéphanie Perreau-Lenza, Carles Sanchis-Seguraa, Miriam Schneidera, Witold Konopkab, Magdalena Westphalb, Gerome Breenc, Sylvane Desrivieresc, Matthias Klugmannd, Camila Guindalinie, Homero Valladag, Ronaldo Laranjeirae, Fernando Rodriguez de Fonsecah, Gunter Schumannc, Günther Schützb, and Rainer Spanagela (2008). "Loss of the Ca²⁺/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine". Proceedings of the National Academy of Sciences of the United States of America (PNAS) 105 (45): 17549–54. doi:10.1073/pnas.0803959105. PMC 2582267. PMID 19001277.
• Feliciano DM and Edelman AM (2009). "Repression of Ca²⁺/calmodulin-dependent protein kinase IV signaling accelerates retinoic acid-induced differentiation of human neuroblastoma cells.". J. Biol. Chem. 284 (39): 26466–81. doi:10.1074/jbc.M109.027680. PMC 2785335. PMID 19633294.