MAPK4

Mitogen-activated protein kinase 4
Identifiers
Symbols	MAPK4 ; ERK-4; ERK4; PRKM4; p63-MAPK; p63MAPK
External IDs	OMIM: 176949 MGI: 2444559 HomoloGene: 2058 ChEMBL: 5759 GeneCards: MAPK4 Gene
EC number	2.7.11.24
Gene ontology Molecular function • MAP kinase activity • protein binding • ATP binding • protein kinase binding • protein homodimerization activity • protein heterodimerization activity Cellular component • nucleus • cytoplasm Biological process • MAPK cascade • protein phosphorylation • cell cycle Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5596	225724
Ensembl	ENSG00000141639	ENSMUSG00000024558
UniProt	P31152	Q6P5G0
RefSeq (mRNA)	NM_001292039	NM_172632
RefSeq (protein)	NP_001278968	NP_766220
Location (UCSC)	Chr 18: 50.56 – 50.73 Mb	Chr 18: 73.93 – 74.07 Mb
PubMed search

Mitogen-activated protein kinase 4 is an enzyme that in humans is encoded by the MAPK4 gene.^[1][2]

Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus where it phosphorylates nuclear targets.^[2]

The Arabidopsis MAPK4 is important in signalling ^[3]

References

1. Li L, Wysk M, Gonzalez FA, Davis RJ (Feb 1994). "Genomic loci of human mitogen-activated protein kinases". Oncogene 9 (2): 647–9. PMID 8290275.
2. "Entrez Gene: MAPK4 mitogen-activated protein kinase 4".
3. Petersen, M. Brodersen, P. Naested, H. Andreasson, E. Lindhart, U. Johansen, B. Nielsen, M. B. Lacy, M., Austin, M. J. Parker, J. E. Sharma, S. B. Klessig, D. F.. Martienssen, R. Mattsson, O. Jensen, A. B. and Mundy, J. Arabidopsis MAP kinase 4 negatively regulates systemic acquired resistance. (2000). "Arabidopsis MAP Kinase 4 Negatively Regulates Systemic Acquired Resistance". Cell 103 (7): 1111–1120. doi:10.1016/S0092-8674(00)00213-0. PMID 11163186.

External links

• MAP Kinase Resource .

Further reading

• Seger R, Krebs EG (1995). "The MAPK signaling cascade". FASEB J. 9 (9): 726–35. PMID 7601337.
• Davis RJ (1996). "Transcriptional regulation by MAP kinases". Mol. Reprod. Dev. 42 (4): 459–67. doi:10.1002/mrd.1080420414. PMID 8607977.
• Robinson MJ, Cobb MH (1997). "Mitogen-activated protein kinase pathways". Curr. Opin. Cell Biol. 9 (2): 180–6. doi:10.1016/S0955-0674(97)80061-0. PMID 9069255.
• Gonzalez FA, Raden DL, Rigby MR, Davis RJ (1992). "Heterogeneous expression of four MAP kinase isoforms in human tissues". FEBS Lett. 304 (2–3): 170–8. doi:10.1016/0014-5793(92)80612-K. PMID 1319925.
• Zhu AX, Zhao Y, Moller DE, Flier JS (1994). "Cloning and characterization of p97MAPK, a novel human homolog of rat ERK-3". Mol. Cell. Biol. 14 (12): 8202–11. PMC 359359. PMID 7969157.
• Kinet S, Bernard F, Mongellaz C, et al. (2002). "gp120-mediated induction of the MAPK cascade is dependent on the activation state of CD4(+) lymphocytes". Blood 100 (7): 2546–53. doi:10.1182/blood-2002-03-0819. PMID 12239168.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Sun M, Wei Y, Yao L, et al. (2006). "Identification of extracellular signal-regulated kinase 3 as a new interaction partner of cyclin D3". Biochem. Biophys. Res. Commun. 340 (1): 209–14. doi:10.1016/j.bbrc.2005.12.003. PMID 16360641.
• Kant S, Schumacher S, Singh MK, et al. (2007). "Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5". J. Biol. Chem. 281 (46): 35511–9. doi:10.1074/jbc.M606693200. PMID 16973613.